(19)

(11)

EP 3 386 514 A2

(12)

(88) Date of publication A3: 22.02.2018 (43) Date of publication: 17.10.2018 Bulletin 2018/42 (21) Application number: 16873806.0 (22) Date of filing: 07.12.2016

(51) International Patent Classification (IPC):  A61K 31/565(2006.01) A61K 9/02(2006.01) (86) International application number: PCT/US2016/065466 (87) International publication number: WO 2017/100378 (15.06.2017 Gazette 2017/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 07.12.2015 US 201562264309 P 17.02.2016 US 201662296552 P 19.04.2016 US 201662324838 P 29.04.2016 US 201662329940 P 10.06.2016 US 201662348820 P (71) Applicant: TherapeuticsMD, Inc. Boca Raton, FL 33487 (US)

(72) Inventors: MIRKIN, Sebastian Boca Raton Florida 33432 (US) AMADIO, Julia M. Boca Raton Florida 33486 (US) BERNICK, Brian Boca Raton Florida 33496 (US) (74) Representative: Murgitroyd & Company  Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)