RECOMBINANT RESPIRATORY SYNCYTIAL VIRUS STRAINS WITH MUTATIONS IN THE M2-2 ORF PROVIDING A RANGE OF ATTENUATION PHENOTYPES - Patent 3386539

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EP 3 386 539 A1

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(43)	Date of publication:
	17.10.2018 Bulletin 2018/42

(21)	Application number: 16822321.2

(22)	Date of filing: 12.12.2016

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International Patent Classification (IPC):

A61K 39/155^(2006.01)
C12N 7/04^(2006.01)

C07K 14/005^(2006.01)

(86)	International application number:
	PCT/US2016/066146

(87)	International publication number:
	WO 2017/100759 (15.06.2017 Gazette 2017/24)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Extension States:
	BA ME
	Designated Validation States:
	MA MD

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Priority:

11.12.2015 US 201562266199 P

(71)	Applicant: The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
	Bethesda, Maryland 20892-7660 (US)

(72)	Inventors:
	COLLINS, Peter, L. Silver Spring MD 20910 (US) BUCHHOLZ, Ursula, J. Silver Spring MD 20901 (US) LUONGO, Cindy Bethesda MD 20814 (US)

(74)	Representative: Gowshall, Jonathan Vallance
	Forresters IP LLP Skygarden Erika-Mann-Strasse 11 80636 München 80636 München (DE)

(54)	RECOMBINANT RESPIRATORY SYNCYTIAL VIRUS STRAINS WITH MUTATIONS IN THE M2-2 ORF PROVIDING A RANGE OF ATTENUATION PHENOTYPES