(19)

(11)

EP 3 393 511 A1

(12)

(43) Date of publication: 31.10.2018 Bulletin 2018/44 (21) Application number: 16880067.0 (22) Date of filing: 21.12.2016

(51) International Patent Classification (IPC):  A61K 39/13(2006.01) A61K 39/20(2006.01) A61P 35/00(2006.01) A61K 39/165(2006.01) A61K 39/25(2006.01) (86) International application number: PCT/US2016/068147 (87) International publication number: WO 2017/112830 (29.06.2017 Gazette 2017/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 21.12.2015 US 201562270148 P 09.04.2016 US 201662320488 P (71) Applicant: La Jolla Institute for Allergy and Immunology La Jolla, CA 92037 (US)	(72) Inventors: HO, Patrick, H. La Jolla, California 92037 (US) KOLLA, Ravi La Jolla, California 92037 (US) (74) Representative: Boult Wade Tennant LLP  Verulam Gardens 70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)