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EP 3 394 032 A1

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(43) Date of publication: 31.10.2018 Bulletin 2018/44 (21) Application number: 16879977.3 (22) Date of filing: 20.12.2016

(51) International Patent Classification (IPC):  C07D 215/233(2006.01) C07D 401/10(2006.01) C07D 239/96(2006.01) A61K 31/4709(2006.01) A61K 31/519(2006.01) C07D 401/04(2006.01) C07D 487/04(2006.01) A61K 31/47(2006.01) A61K 31/517(2006.01) A61P 33/02(2006.01) (86) International application number: PCT/US2016/067795 (87) International publication number: WO 2017/112678 (29.06.2017 Gazette 2017/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 21.12.2015 US 201562270264 P 10.03.2016 US 201662306385 P (71) Applicants: The University of Chicago Chicago, IL 60637 (US) Institute for Systems Biology Seattle, WA 98109 (US) University of Leeds Leeds, LS2 9JT (GB) The J. Craig Venter Institute Rockville MD 20850 (US) The University of Strathclyde Glasgow G1 1XQ (GB) U.S. Government, as represented by The Secretary of the Army Medical Command (MEDCOM) Fort Detrick MD 21702-5012 (US)

(72) Inventors: MCLEOD, Rima Chicago, IL 60637 (US) MCPHILLIE, Martin Leeds LS2 9JT (GB) FISHWICK, Colin, W.g. Leeds LS2 9JT (GB) LORENZI, Hernan, Alejandro Rockville, MD 20850 (US) WANG, Kai Seattle, WA 98109 (US) KIM, Teak-kyun Seattle, WA 98109 (US) ZHOU, Yong Seattle, WA 98109 (US) HOOD, Leroy, E. Seattle, WA 98109 (US) ZHOU, Ying Chicago, IL 60637 (US) EL BISSATI, Kamal Chicago, IL 60637 (US) GORDON, James Leeds LS2 9JT (GB) HICKMAN, Mark Silver Spring, MD 20910 (US) LI, QiGui Silver Spring, MD 20910 (US) ROBERTS, Craig Glasgow, G1 RD (US) (74) Representative: Beck Greener  Fulwood House 12 Fulwood Place London WC1V 6HR London WC1V 6HR (GB)