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EP 3 394 090 A1

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(43) Date of publication: 31.10.2018 Bulletin 2018/44 (21) Application number: 16874176.7 (22) Date of filing: 14.12.2016

(51) International Patent Classification (IPC):  C07K 14/575(2006.01) A61K 38/22(2006.01) A61P 5/48(2006.01) A61P 9/10(2006.01) C07K 1/113(2006.01) A61P 3/10(2006.01) A61P 5/50(2006.01) A61P 25/28(2006.01) (86) International application number: PCT/BR2016/050330 (87) International publication number: WO 2017/100896 (22.06.2017 Gazette 2017/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 14.12.2015 BR 102015312830 (71) Applicant: Universidade Federal Do Rio De Janeiro CEP 21941-901 Rio de Janeiro RJ (BR)

(72) Inventors: DA ROCHA E LIMA, Luis, Mauricio, Trambaioli 22470-130 Rio de Janeiro - RJ (BR) ROSADO, Luiz, Henrique, Guerreiro 23835-180 Rio de Janeiro - RJ (BR) GUTERRES, Mariana, Fernandes De Avila Netto 21330-600 Rio de Janeiro - RJ (BR) FERREIRA, Bruno, Melo Vieira Gonçalves 20270-002 Rio de Janeiro - RJ (BR) (74) Representative: Nederlandsch Octrooibureau  P.O. Box 29720 2502 LS The Hague 2502 LS The Hague (NL)