(19)

(11)

EP 3 397 404 A2

(12)

(88) Date of publication A3: 28.09.2017 (43) Date of publication: 07.11.2018 Bulletin 2018/45 (21) Application number: 16882432.4 (22) Date of filing: 22.12.2016

(51) International Patent Classification (IPC):  B07C 5/00(2006.01) (86) International application number: PCT/US2016/068337 (87) International publication number: WO 2017/116997 (06.07.2017 Gazette 2017/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 31.12.2015 US 201562274133 P 29.02.2016 US 201662301365 P (71) Applicant: Counsyl, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: LAPHAM, Kyle South San Francisco California 94080 (US) NASH, Ethan South San Francisco California 94080 (US) TURNER, Peter South San Francisco California 94080 (US) HAAS, Kevin South San Francisco California 94080 (US) WONG, Christopher South San Francisco California 94080 (US) (74) Representative: Hutter, Anton et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)