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EP 3 397 639 A1

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(43) Date of publication: 07.11.2018 Bulletin 2018/45 (21) Application number: 16826561.9 (22) Date of filing: 22.12.2016

(51) International Patent Classification (IPC):  C07D 471/16(2006.01) A61P 31/18(2006.01) A61K 31/5025(2006.01) (86) International application number: PCT/US2016/068173 (87) International publication number: WO 2017/116928 (06.07.2017 Gazette 2017/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 31.12.2015 WO PCT/CN2015/100106 (71) Applicant: Merck Sharp & Dohme Corp. Rahway, NJ 07065-0907 (US)

(72) Inventors: YU, Tao Kenilworth New Jersey 07033 (US) WADDELL, Sherman, T. Westfield New Jersey 07090 (US) GRAHAM, Thomas, H. Boston Massachusetts 02115-5727 (US) ZHANG, Yonglian Kenilworth New Jersey 07033 (US) MCCAULEY, John, A. West Point Pennsylvania 19486 (US) STAMFORD, Andrew, W. Chatham Township New Jersey 07928 (US) CAI, Jiaqiang Shanghai 200131 (CN) QI, Zhiqi Shanghai 200131 (CN) (74) Representative: Jaap, David Robert  MSD Hertford Road Hoddesdon, Herts EN11 9BU Hoddesdon, Herts EN11 9BU (GB)