ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................J2.0.21 - 2999001/03406242CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120230712W154deBibliographieenBibliographyfrBibliographieEP18180517.7201108172019052820200123enenen20101378520100817GB2023071220232820181128201848202306072023232022070420230712202328A61K 31/00 20060101AFI20181022BHEP A61K 38/04 20060101ALI20181022BHEP A61P 1/16 20060101ALI20181022BHEP A61P 13/12 20060101ALI20181022BHEP A61K 38/04 20130101 LI20130101BHEP G01N 33/6893 20130101 LI20130101BHEP G01N2333/705 20130101 LA20130101BHEP G01N2500/00 20130101 LA20130101BHEP G01N2800/085 20130101 LA20130101BHEP G01N2800/28 20130101 LA20130101BHEP G01N2800/347 20130101 LA20130101BHEP G01N2800/52 20130101 LA20130101BHEP A61K 38/10 20130101 FI20131127BHEP A61P 1/16 20180101 LI20200318BHEP A61P 13/12 20180101 LI20200319BHEP deTLR4 ANTAGONIST ZUR BEHANDLUNG VON ERHÖHTEN PLASMA AMMONIAK WERTENenTLR4 ANTAGONIST FOR USE IN THE TREATMENT OF INCREASED AMMONIA PLASMA LEVELSfrANTAGONISTE DU TLR4 DESTINÉ À ÊTRE UTILISÉ DANS LE TRAITEMENT DE L'AUGMENTATION DES TAUX PLASMATIQUES D'AMMONIACKITAZAWA TOSHIYUKI ET AL: "Therapeutic approach to regulate innate immune response by Toll-like receptor 4 antagonist E5564 in rats with D-galactosamine-induced acute severe liver injury", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY INTERSCIENCE, MELBOURNE, AU, vol. 24, no. 6, 1 June 2009 (2009-06-01), pages 1089-1094, XP009152110, ISSN: 0815-9319, DOI: 10.1111/J.1440-1746.2008.05770.X [retrieved on 2009-02-15]CUNNINGHAM PATRICK N ET AL: "Role of toll-like receptor 4 in endotoxin-induced acute renal failure.", JOURNAL OF IMMUNOLOGY, vol. 172, no. 4, 15 February 2004 (2004-02-15), pages 2629-2635, XP009152192, ISSN: 0022-1767ZAGER RICHARD A ET AL: "Toll-like receptor (TLR4) shedding and depletion: acute proximal tubular cell responses to hypoxic and toxic injury", AMERICAN JOURNAL OF PHYSIOLOGY: RENAL PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, UNITED STATES, vol. 292, no. 1, 1 January 2007 (2007-01-01), pages F304-F312, XP009152133, ISSN: 1931-857X, DOI: 10.1152/AJPRENAL.00237.2006 [retrieved on 2006-08-01]SEKI EKIHIRO ET AL: "TLR4 mediates inflammation and fibrogenesis after bile duct ligation", HEPATOLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 42, no. 4, Suppl. 1, 1 October 2005 (2005-10-01), pages 265A-266A, XP009152038, ISSN: 0270-9139 [retrieved on 2005-10-05]11748969.0260576320110817JALAN, Rajiv9 Duggan DriveChislehurst, BR7 5EPGBSHAH, Naina5 Alpha House 52 Canning RoadCroydon, CR0 6QFGBYaqrit Limited101934517N111698D-EPThe Elms Courtyard BromesberrowLedbury HR8 1RZGBJ A Kemp LLP10166966680 Turnmill StreetLondon EC1M 5QUGBALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTR