(19)
(11) EP 3 411 120 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.06.2023 Bulletin 2023/25

(45) Mention of the grant of the patent:
10.05.2023 Bulletin 2023/19

(21) Application number: 17748124.9

(22) Date of filing: 02.02.2017
(51) International Patent Classification (IPC): 
A61P 1/00(2006.01)
G01N 33/48(2006.01)
 C12Q 1/00(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 16/241; C07K 16/2839; A61K 2039/505; A61K 2039/55; C07K 2317/21; C07K 2317/24; G01N 2800/065; G01N 2800/52; G01N 33/6893; A61P 1/00; A61K 31/4035; A61K 31/4245; A61K 31/427; A61K 31/496; A61K 31/519
(86) International application number:
PCT/US2017/016152
(87) International publication number:
WO 2017/136511 (10.08.2017 Gazette 2017/32)

(54)

ASSESSMENT OF INTESTINAL BARRIER FUNCTION TO IMPROVE TREATMENT OF INFLAMMATORY BOWEL DISEASE

BEURTEILUNG DER DARMBARRIEREFUNKTION ZUR VERBESSERUNG DER BEHANDLUNG VON ENTZÜNDLICHER DARMERKRANKUNG

ÉVALUATION DE LA FONCTION DE BARRIÈRE INTESTINALE POUR AMÉLIORER LE TRAITEMENT D'UNE MALADIE INTESTINALE INFLAMMATOIRE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 02.02.2016 US 201662290201 P
15.12.2016 US 201662434741 P

(43) Date of publication of application:
12.12.2018 Bulletin 2018/50

(60) Divisional application:
23171699.4

(73) Proprietor: Maximus Diagnostic Technologies LLC
Decatur, GA 30030 (US)

(72) Inventor:
  • LIU, Julia, J.
    Little Rock, AR 72223 (US)

(74) Representative: Nederlandsch Octrooibureau 
P.O. Box 29720
2502 LS The Hague
2502 LS The Hague (NL)


(56) References cited: : 
WO-A1-2010/062663
WO-A1-2014/055824
WO-A2-2013/080050
 WO-A1-2014/039699
WO-A1-2015/083085
   
  • JULIA J LIU ET AL: "Mind The Gaps: Confocal Endomicroscopy Showed Increased Density of Small Bowel Epithelial Gaps in Inflammatory Bowel Disease", JOURNAL OF CLINICAL GASTROENTEROLOGY., vol. 45, no. 3, 1 March 2011 (2011-03-01), pages 240-245, XP055225764, US ISSN: 0192-0790, DOI: 10.1097/MCG.0b013e3181fbdb8a
  • JULIA J. LIU ET AL: "Epithelial Cell Extrusion Leads to Breaches in the Intestinal Epithelium", HHS PUBLIC ACCESS AUTHOR MANUSCRIPT, vol. 19, no. 5, 1 April 2013 (2013-04-01), pages 912-921, XP55225768, US ISSN: 1078-0998, DOI: 10.1097/MIB.0b013e3182807600
  • M F NEURATH: "New targets for mucosal healing and therapy in inflammatory bowel diseases", MUCOSAL IMMUNOLOGY, vol. 7, no. 1, 2 October 2013 (2013-10-02) , pages 6-19, XP055111526, ISSN: 1933-0219, DOI: 10.1038/mi.2013.73
  • SANDBORN: 'New Targets for Small Molecules in Inflammatory Bowel Disease' GASTROENTEROLOGY & HOPATOLOGY vol. 11, no. 5, May 2015, pages 338 - 340, XP055404179
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).