(19)

(11)

EP 3 411 470 A2

(12)

(88) Date of publication A3: 14.09.2017 (43) Date of publication: 12.12.2018 Bulletin 2018/50 (21) Application number: 17748084.5 (22) Date of filing: 01.02.2017

(51) International Patent Classification (IPC):  C12N 5/02(2006.01) C12N 5/0793(2010.01) C12N 5/074(2010.01) C12N 5/0797(2010.01) (86) International application number: PCT/US2017/016079 (87) International publication number: WO 2017/136462 (10.08.2017 Gazette 2017/32)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 01.02.2016 US 201662289521 P 06.05.2016 US 201662332849 P 23.06.2016 US 201662354040 P 21.12.2016 US 201662437314 P (71) Applicants: Emulate, Inc. Boston, MA 02110 (US) Cedars-Sinai Medical Center Los Angeles, CA 90048 (US)

(72) Inventors: KERNS, S. Jordan Reading MA 01867 (US) WEN, Norman West Roxbury MA 02132 (US) LUCCHESI, Carol Westwood MA 02090 (US) HINOJOSA, Christopher David Malden, MA 02148 (US) FRASER, Jacob Somerville MA 02144 (US) PUERTA, Jefferson Malden MA 02148 (US) HAMILTON, Geraldine Boston, MA 02127 (US) BARRETT, Robert Los Angeles CA 90012 (US) SVENDSEN, Clive Pacific Palisades CA 90272 (US) LEVNER, Daniel Brookline MA 02446 (US) TARGAN, Stephen R. Santa Monica CA 90402 (US) WORKMAN, Michael Santa Monica CA 90402 (US) SAREEN, Dhruv Porter Ranch CA 91326 (US) RAJAMANI, Uthra Los Angeles CA 90068 (US) KASENDRA, Magdalena Boston, MA 02215 (US) (74) Representative: McNab, Donald C.  Marks & Clerk LLP 40 Torphichen Street Edinburgh EH3 8JB Edinburgh EH3 8JB (GB)