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(11)

EP 3 413 961 A1

(12)

(43) Date of publication: 19.12.2018 Bulletin 2018/51 (21) Application number: 17750906.4 (22) Date of filing: 10.02.2017

(51) International Patent Classification (IPC):  A61M 25/00(2006.01) A61M 5/14(2006.01) A61M 1/36(2006.01) (86) International application number: PCT/US2017/017545 (87) International publication number: WO 2017/139691 (17.08.2017 Gazette 2017/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 12.02.2016 US 201662294901 P (71) Applicant: Cedars-Sinai Medical Center Los Angeles, CA 90048 (US)	(72) Inventors: HACKNER, Dani Los Angeles California 90048 (US) BAKER, Michael J. Portland California 97204 (US) WEY, Gene Victoria British Columbia V8Z 1E7 (CA) (74) Representative: Hutter, Anton et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)