(19)
(11) EP 3 415 635 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.09.2021 Bulletin 2021/37

(45) Mention of the grant of the patent:
04.08.2021 Bulletin 2021/31

(21) Application number: 17175573.9

(22) Date of filing: 12.06.2017
(51) International Patent Classification (IPC): 
C12Q 1/6881(2018.01)
C12Q 1/6883(2018.01)
(52) Cooperative Patent Classification (CPC):
C12Q 1/6881; C12Q 1/6883; C12Q 2600/154; C12Q 2600/148

(54)

AGE DETERMINATION OF A HUMAN INDIVIDUAL

ALTERSBESTIMMUNG EINES MENSCHEN

DÉTERMINATION DE L'ÂGE D'UN INDIVIDU HUMAIN


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(43) Date of publication of application:
19.12.2018 Bulletin 2018/51

(73) Proprietor: Beiersdorf AG
20253 Hamburg (DE)

(72) Inventors:
  • WINNEFELD, Marc
    22880 Wedel (DE)
  • WURZER, Elisabeth
    20255 Hamburg (DE)
  • KRISTOF, Boris
    25469 Halsetenbek (DE)
  • KADERALI, Lars
    17493 Greifswald (DE)

(74) Representative: Haseltine Lake Kempner LLP 
Bürkleinstrasse 10
80538 München
80538 München (DE)


(56) References cited: : 
WO-A2-2013/033627
US-A1- 2015 259 742
CN-B- 104 357 561
   
  • FELIX BORMANN ET AL: "Reduced DNA methylation patterning and transcriptional connectivity define human skin aging", AGING CELL, vol. 15, no. 3, 23 March 2016 (2016-03-23) , pages 563-571, XP055400994, GB ISSN: 1474-9718, DOI: 10.1111/acel.12470
  • Anonymous: "Infinium HumanMethylation450 BeadChip", Illumina , 9 March 2012 (2012-03-09), XP055401052, Retrieved from the Internet: URL:https://support.illumina.com/content/d am/illumina-marketing/documents/products/d atasheets/datasheet_humanmethylation450.pd f [retrieved on 2017-08-24]
  • Carmen M Koch ET AL: "Epigenetic-aging-signature to determine age in different tissues", Aging, 1 October 2011 (2011-10-01), pages 1018-1027, XP055160615, United States DOI: 10.18632/aging.100395 Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/pubmed/220 67257 [retrieved on 2015-01-08]
  • LINDSAY M. REYNOLDS ET AL: "Age-related variations in the methylome associated with gene expression in human monocytes and T cells", NATURE COMMUNICATIONS, vol. 5, 18 November 2014 (2014-11-18), page 5366, XP055428472, DOI: 10.1038/ncomms6366 -& L Reynolds ET AL: "Age-related variations in the methylome associated with gene expression in human monocytes and T cells - Supplementary Table 1", Nature communications, 18 November 2014 (2014-11-18), XP055428477, Retrieved from the Internet: URL:http://www.nature.com/articles/ncomms6 366 [retrieved on 2017-11-24]
  • Anonymous: "Direct Cycle Sequencing Kit Limited Use Label License: Research Use Only", , 1 February 2011 (2011-02-01), XP55726710, Retrieved from the Internet: URL:https://tools.thermofisher.com/content /sfs/manuals/cms_091370.pdf [retrieved on 2020-09-01]
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).