(19)

(11)

EP 3 426 658 A1

(12)

(43) Date of publication: 16.01.2019 Bulletin 2019/03 (21) Application number: 17711992.2 (22) Date of filing: 10.03.2017

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61K 8/49(2006.01) C07D 209/12(2006.01) (86) International application number: PCT/US2017/021843 (87) International publication number: WO 2017/156424 (14.09.2017 Gazette 2017/37)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 10.03.2016 US 201662306468 P (71) Applicants: Einziger, Michael Santa Monica, CA 90405 (US) Simpson, Ann Marie Santa Monica, CA 90405 (US)	(72) Inventors: Einziger, Michael Santa Monica, CA 90405 (US) Simpson, Ann Marie Santa Monica, CA 90405 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)