(19)
(11) EP 3 430 406 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
28.04.2021 Bulletin 2021/17

(45) Mention of the grant of the patent:
02.12.2020 Bulletin 2020/49

(21) Application number: 17767588.1

(22) Date of filing: 17.03.2017
(51) International Patent Classification (IPC): 
G01N 33/574(2006.01)
(86) International application number:
PCT/US2017/022853
(87) International publication number:
WO 2017/161215 (21.09.2017 Gazette 2017/38)

(54)

METHOD FOR CANCER DIAGNOSIS AND PROGNOSIS

VERFAHREN ZUR KREBSDIAGNOSE UND -PROGNOSE

MÉTHODE DE DIAGNOSTIC ET DE PRONOSTIC D'UN CANCER


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 17.03.2016 US 201662309766 P

(43) Date of publication of application:
23.01.2019 Bulletin 2019/04

(73) Proprietors:
  • Chang Gung University
    Taoyuan City 333 (TW)
  • Linkou Chang Gung Memorial Hospital
    Taoyuan City 333 (TW)

(72) Inventors:
  • CHANG, Yu-Sun
    San Francisco, CA 94109 (US)
  • YU, Jau-Song
    Taoyuan City 320 (TW)
  • CHEN, Yi-Ting
    Taoyuan City 325 (TW)
  • CHIANG, Wei-Fan
    Tainan City 701 (TW)
  • HSIAO, Yung-Chin
    New Taipei City 238 (TW)
  • SEE, Lai-Chu
    Taoyuan City 333 (TW)
  • CHANG, Kai-Ping
    Taipei City 112 (TW)

(74) Representative: Lang, Christian 
LangPatent Anwaltskanzlei IP Law Firm Ingolstädter Straße 5
80807 München
80807 München (DE)


(56) References cited: : 
US-A1- 2012 231 468
US-A1- 2014 235 487
   
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  • KIM KI-YEOL ET AL: "Combined genomic expressions as a diagnostic factor for oral squamous cell carcinoma", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 103, no. 5, 8 December 2013 (2013-12-08), pages 317-322, XP029006184, ISSN: 0888-7543, DOI: 10.1016/J.YGENO.2013.11.007
  • Eric Roman ET AL: "Analysis of protein expression profile of oral squamous cell carcinoma by MALDI-TOF", Anticancer Research 33(3), 31 March 2013 (2013-03-31), pages 837-845, XP055627694, Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/pubmed/234 82752 [retrieved on 2019-10-01]
  • UTA J. E. THIEL ET AL: "Analysis of differentially expressed proteins in oral squamous cell carcinoma by MALDI-TOF MS : Proteome analysis of OSCC", JOURNAL OF ORAL PATHOLOGY AND MEDICINE, vol. 40, no. 5, 1 May 2011 (2011-05-01), pages 369-379, XP055627703, DK ISSN: 0904-2512, DOI: 10.1111/j.1600-0714.2010.00982.x
  • CHIH-CHING WU ET AL: "Saliva proteome profiling reveals potential salivary biomarkers for detection of oral cavity squamous cell carcinoma : Identification of salivary biomarkers for oral cancer detection", PROTEOMICS, vol. 15, no. 19, 1 October 2015 (2015-10-01), pages 3394-3404, XP055627708, DE ISSN: 1615-9853, DOI: 10.1002/pmic.201500157
  • Lang-Ming Chi ET AL: "Enhanced Interferon Signaling Pathway in Oral Cancer Revealed by Quantitative Proteome Analysis of Microdissected Specimens Using 16 O/ 18 O Labeling and Integrated Two-dimensional LC-ESI-MALDI Tandem MS* - S", & Cellular Proteomics, 1 January 2009 (2009-01-01), pages 1453-1474, XP055627713, Retrieved from the Internet: URL:https://www.ncbi.nlm.nih.gov/pmc/artic les/PMC2709179/pdf/zjw1453.pdf [retrieved on 2019-10-01]
  • MULLER R ET AL: "Logistic regression and CART in the analysis of multimarker studies", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 394, no. 1-2, 1 August 2008 (2008-08-01), pages 1-6, XP022706069, ISSN: 0009-8981, DOI: 10.1016/J.CCA.2008.04.007 [retrieved on 2008-04-12]
  • XIA ET AL.: 'Glucose-regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance' WORLD J SURG ONCOL vol. 12, no. 1, 25 April 2014, pages 1 - 8, XP021184881
  • YU ET AL.: 'Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan' PROC NAT ACAD SCI vol. 113, no. 41, 23 September 2016, pages 11549 - 11554, XP055422749
   
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