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EP 3 433 352 A1

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(43) Date of publication: 30.01.2019 Bulletin 2019/05 (21) Application number: 17711120.0 (22) Date of filing: 14.03.2017

(51) International Patent Classification (IPC):  C12M 1/06(2006.01) C12M 1/26(2006.01) C12M 1/00(2006.01) (86) International application number: PCT/EP2017/055892 (87) International publication number: WO 2017/162467 (28.09.2017 Gazette 2017/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 21.03.2016 US 201615075211 (71) Applicant: General Electric Company Schenectady, NY 12345 (US)	(72) Inventors: DAVIS, Brian, Michael Niskayuna New York 12309 (US) CONWAY, Kenneth, Roger Niskayuna New York 12309 (US) ZHANG, Xiaohua Niskayuna New York 12309 (US) (74) Representative: Aldenbäck, Ulla Christina  GE Healthcare Bio-Sciences AB Patent Department Björkgatan 30 751 84 Uppsala 751 84 Uppsala (SE)