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(11)

EP 3 436 026 A1

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(43) Date of publication: 06.02.2019 Bulletin 2019/06 (21) Application number: 17748403.7 (22) Date of filing: 28.03.2017

(51) International Patent Classification (IPC):  A61K 31/592(2006.01) A61P 3/02(2006.01) A61K 31/593(2006.01) A61P 13/12(2006.01) (86) International application number: PCT/EP2017/057282 (87) International publication number: WO 2017/182237 (26.10.2017 Gazette 2017/43)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 28.03.2016 US 201662314359 P (71) Applicant: OPKO Ireland Global Holdings, Ltd. Grand Cayman KY1-9006 (KY)	(72) Inventors: MELNICK, Joel Z. Miami Beach, Florida 33141 (US) BISHOP, Charles W. Miami Beach, Florida 33141 (US) PETKOVICH, P. Martin Kingston, Ontario K7M 4E8 (CA) STRUGNELL, Stephen A. Bay Harbor Islands, Florida 33154 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)