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EP 3 436 481 A1

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(43) Date of publication: 06.02.2019 Bulletin 2019/06 (21) Application number: 17715372.3 (22) Date of filing: 24.03.2017

(51) International Patent Classification (IPC):  C07K 16/30(2006.01) A61P 35/00(2006.01) C07K 16/28(2006.01) A61K 47/68(2017.01) (86) International application number: PCT/US2017/024027 (87) International publication number: WO 2017/172518 (05.10.2017 Gazette 2017/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 29.03.2016 US 201662314652 P 12.07.2016 US 201662361312 P (71) Applicants: STCUBE, INC. Gangnam-gu, Seoul, 06164 (KR) Board Of Regents, The University Of Texas System Austin, TX 78701 (US)

(72) Inventors: YOO, Stephen S. Centreville Virginia 20120 (US) CHUNG, Ezra M. North Potomac Maryland 20878 (US) KIM, Yong-Soo Rockville Maryland 20852 (US) HAN, Kyu Lee Gaithersburg Maryland 20878 (US) PARK, Andrew H. Gaithersburg Maryland 20879 (US) HUNG, Mien-Chie Houston Texas 77096 (US) LI, Chia-Wei Houston Texas 77030 (US) LIM, Seung-Oe Houston Texas 77030 (US) (74) Representative: Appleyard Lees IP LLP  15 Clare Road Halifax HX1 2HY Halifax HX1 2HY (GB)