ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................*JBDM Ver 2.0.16 (1th of February 2022) - 2999001/03436606CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120230315W173deBibliographieenBibliographyfrBibliographieEP17772917.5201703312018092820200904enenen201662317170 P20160401US2023031520231120190206201906202302222023082022091620230315202311C12Q 1/6883 20180101AFI20220826BHEP C07H 21/04 20060101ALI20220826BHEP C12N 15/10 20060101ALI20220826BHEP C12P 19/34 20060101ALI20220826BHEP C12N 15/10 20130101 LI20171026BHEP C12Q 1/6883 20130101 FI20190418BHEP deZELLFREIE MITOCHONDRIALE DESOXYRIBONUKLEINSÄURE AUS PLASMAenPLASMA DERIVED CELL-FREE MITOCHONDRIAL DEOXYRIBONUCLEIC ACIDfrACIDE DÉSOXYRIBONUCLÉIQUE MITOCHONDRIAL ACELLULAIRE DÉRIVÉ DU PLASMACN-A- 105 087 767CN-B- 101 270 390Illumina: "Document # 15037958 v01 Human mtDNA Genome For the Illumina Sequencing Platform Revision History 1 Introduction 3 Workflow 5 Perform First Amplification 6 Quantify DNA 8 Tagment Input DNA 10 Perform Second Amplification 12 Perform Second DNA Clean Up 15 Bead-based Normalization 17 Pool Bead-Based No", , 1 February 2016 (2016-02-01), XP055615463, Retrieved from the Internet: URL:https://support.illumina.com/content/d am/illumina-support/documents/documentatio n/chemistry_documentation/samplepreps_lega cy/human-mtdna-genome-guide-15037958-01.pd f [retrieved on 2019-08-26]CHRISTOPHER NEWELL ET AL: "Plasma-derived cell-free mitochondrial DNA: A novel non-invasive methodology to identify mitochondrial DNA haplogroups in humans", MOLECULAR GENETICS AND METABOLISM, vol. 125, no. 4, 1 December 2018 (2018-12-01), pages 332-337, XP055615617, AMSTERDAM, NL ISSN: 1096-7192, DOI: 10.1016/j.ymgme.2018.10.002LIU, J. et al.: "Circulating cell -free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus", J DIABETES INVESTIG, vol. 15, no. 1, 1 January 2016 (2016-01-01), pages 109-114, XP055578694, ISSN: 2040-1116, DOI: 10.1111/jdi.12366XIA, P. et al.: "Simultaneous quantitative assessment of circulating cell -free mitochondrial and nuclear DNA by multiplex real-time PCR", GENETICS AND MOLECULAR BIOLOGY, vol. 32, no. 1, 1 January 2009 (2009-01-01), pages 20-24, XP055404314, DOI: doi:10.1590/S1415-47572009000100003DE VLAMINCK, I. et al.: "Circulating Cell -Free DNA Enables Noninvasive Diagnosis of Heart Transplant Rejection", SCI TRANS MED, vol. 6, no. 241, 18 June 2014 (2014-06-18) , pages 1-19, XP002744939, DOI: doi:10.1126/scitranslmed.3007803HIDESTRAND, M. et al.: "Highly Sensitive Non-Invasive Cardiac Transplant Rejection Monitoring Using Targeted Quantification of Donor Specific Cell Free DNA", J AM COLL CARDIOL, vol. 63, no. 12, 1 April 2014 (2014-04-01) , pages 1224-1226, XP028831507, DOI: 10.1016/j.jacc.2013.09.029EVANS, M. J. et al.: "Mitochondrial DNA genotypes in nuclear transfer-derived cloned sheep", NAT GENET, vol. 23, no. 1, 1 September 1999 (1999-09-01), pages 90-93, XP002946451, ISSN: 1061-4036, DOI: doi:10.1038/12696KHAN, A. et al.: "An Algorithm Measuring Donor Cell -Free DNA in Plasma of Cellular and Solid Organ Transplant Recipients That Does Not Require Donor or Recipient Genotyping", FRONTIERS IN CARDIOVASCULAR MEDICINE, vol. 3, no. 33, 22 September 2016 (2016-09-22), pages 1-10, XP055440493, DOI: 10.3389/fcvm.2016.0003320191217KHAN, AnealCalgary, Alberta T2E 7Z4CANEWELL, Christopherc/o UTI Limited Partnership 3553-31st Street NWCalgary, Alberta T2L 2K7CAHUME, Stacey8-27 MSB University of AlbertaEdmonton, Alberta T6C 2H7CAGREENWAY, Stevenc/o UTI Limited Partnership 3553-31st Street NWCalgary, Alberta T2L 2K7CAM.A.G.I.C. Clinic Ltd.101981459XII 2149/20WOEP/jw215 - 971 64 Ave NECalgary AB T2E 7Z4CAHertin und Partner Rechts- und Patentanwälte PartG mbB101426058Kurfürstendamm 54/5510707 BerlinDEALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTRCA201705040520170331enWO201716598220171005201740