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(11)

EP 3 442 532 A1

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(43) Date of publication: 20.02.2019 Bulletin 2019/08 (21) Application number: 17782552.8 (22) Date of filing: 17.04.2017

(51) International Patent Classification (IPC):  A61K 31/47(2006.01) A61K 9/48(2006.01) A61P 35/00(2006.01) A61K 9/20(2006.01) A61K 31/436(2006.01) (86) International application number: PCT/JP2017/015461 (87) International publication number: WO 2017/179739 (19.10.2017 Gazette 2017/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 15.04.2016 JP 2016081787 15.04.2016 US 201662322916 P (71) Applicant: Eisai R&D Management Co., Ltd. Tokyo 112-8088 (JP)	(72) Inventor: KREMER, Alton Woodcliff Lake NJ 07677 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)