| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
15.04.2016 US 201662323589 P
|
| (43) |
Date of publication of application: |
|
20.02.2019 Bulletin 2019/08 |
| (73) |
Proprietors: |
|
- Natera, Inc.
San Carlos, CA 94070 (US)
- UCL Business Ltd
London WC1E 6BT (GB)
|
|
| (72) |
Inventors: |
|
- ZIMMERMANN, Bernhard
San Carlos, California 94070 (US)
- CONSTANTIN, Tudor Pompiliu
San Carlos, California 94070 (US)
- SALARI, Raheleh
San Carlos, California 94070 (US)
- KIRKIZLAR, Huseyin Eser
Los Angeles, California 90026 (US)
- SWANTON, Robert Charles
London
Greater London WC1E 6BT (GB)
- JAMAL-HANJANI, Mariam
London
Greater London WC1E 6BT (GB)
- ABBOSH, Christopher
London
Greater London WC1E 6BT (GB)
- WILSON, Gareth
London
Greater London NW1 1AT (GB)
|
| (74) |
Representative: Gibbs, Richard |
|
Marks & Clerk LLP
Aurora
120 Bothwell Street
Glasgow G2 7JS
Glasgow G2 7JS (GB) |
| (56) |
References cited: :
WO-A1-2014/151117
|
WO-A1-2015/164432
|
|
| |
|
|
- M. JAMAL-HANJANI ET AL: "Detection of ubiquitous and heterogeneous mutations in cell-free
DNA from patients with early-stage non-small-cell lung cancer", ANNALS OF ONCOLOGY.,
vol. 27, no. 5, 28 January 2016 (2016-01-28), pages 862-867, XP055407182, NL ISSN:
0923-7534, DOI: 10.1093/annonc/mdw037
- A. NARAYAN ET AL: "Ultrasensitive Measurement of Hotspot Mutations in Tumor DNA in
Blood Using Error-Suppressed Multiplexed Deep Sequencing", CANCER RESEARCH, vol. 72,
no. 14, 15 July 2012 (2012-07-15) , pages 3492-3498, XP055407873, US ISSN: 0008-5472,
DOI: 10.1158/0008-5472.CAN-11-4037
- XU SONG ET AL: "Circulating tumor DNA identified by targeted sequencing in advanced-stage
non-small cell lung cancer patients", CANCER LETTERS, NEW YORK, NY, US, vol. 370,
no. 2, 12 November 2015 (2015-11-12), pages 324-331, XP029337565, ISSN: 0304-3835,
DOI: 10.1016/J.CANLET.2015.11.005
- Anonymus: "Ion AmpliSeq Cancer Hotspot Panel v2", , 2015, XP055409371, Retrieved from
the Internet: URL:https://tools.thermofisher.com/content /sfs/brochures/Ion-AmpliSeq-Cancer-Hotspot
-Panel-Flyer.pdf [retrieved on 2017-09-25]
- E. C. DE BRUIN ET AL: "Spatial and temporal diversity in genomic instability processes
defines lung cancer evolution", SCIENCE, vol. 346, no. 6206, 10 October 2014 (2014-10-10),
pages 251-256, XP055409531, ISSN: 0036-8075, DOI: 10.1126/science.1253462
- MARIAM JAMAL-HANJANI ET AL: "Community Page Tracking Genomic Cancer Evolution for
Precision Medicine: The Lung TRACERx Study", PLOS BIOLOGY, vol. 12, no. 7, July 2014
(2014-07), page e1001906, XP055295763, DOI: 10.1371/journal.pbio.1001906
- CHRISTOPHER ABBOSH ET AL: "Phylogenetic ctDNA analysis depicts early-stage lung cancer
evolution", NATURE, vol. 545, no. 7655, 26 April 2017 (2017-04-26), pages 446-451,
XP055409582, ISSN: 0028-0836, DOI: 10.1038/nature22364
- Couraud Sébastien ET AL: "Noninvasive Diagnosis of Actionable Mutations by Deep Sequencing
of Circulating Free DNA in Lung Cancer from Never-Smokers: A Proof-of-Concept Study
from BioCAST/IFCT-1002", CLINICAL CANCER RESEARCH, vol. 20, no. 17, 1 September 2014
(2014-09-01), pages 4613-4624, XP55813405, US ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-13-3063
|
|
