(19)

(11)

EP 3 445 381 A1

(12)

(43) Date of publication: 27.02.2019 Bulletin 2019/09 (21) Application number: 17786644.9 (22) Date of filing: 20.04.2017

(51) International Patent Classification (IPC):  A61K 35/76(2015.01) C12N 15/86(2006.01) C12N 15/866(2006.01) C12N 15/09(2006.01) C12N 5/10(2006.01) C12N 7/00(2006.01) (86) International application number: PCT/US2017/028660 (87) International publication number: WO 2017/184879 (26.10.2017 Gazette 2017/43)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 21.04.2016 US 201662325817 P (71) Applicant: Virovek, Inc. Hayward CA 94541-7010 (US)	(72) Inventor: CHEN, Haifeng Piedmont California 94611 (US) (74) Representative: FRKelly  27 Clyde Road Dublin D04 F838 Dublin D04 F838 (IE)