(19)

(11)

EP 3 448 408 A1

(12)

(43) Date of publication: 06.03.2019 Bulletin 2019/10 (21) Application number: 17722497.9 (22) Date of filing: 25.04.2017

(51) International Patent Classification (IPC):  A61K 38/04(2006.01) A61K 31/365(2006.01) C07D 303/36(2006.01) A61K 38/06(2006.01) A61K 31/4015(2006.01) A61K 38/12(2006.01) A61K 31/69(2006.01) A61P 35/00(2006.01) A61K 45/06(2006.01) (86) International application number: PCT/GB2017/051148 (87) International publication number: WO 2017/187156 (02.11.2017 Gazette 2017/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 26.04.2016 GB 201607279 (71) Applicant: Big DNA Ltd Roslin, Midlothian EH25 9PP (GB)	(72) Inventors: MARCH, John, Bernard Roslin Midlothian EH25 9PP (GB) CLARK, Ewan, McIntosh Roslin Midlothian EH25 9PP (GB) (74) Representative: HGF Limited  1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)