(19)
(11) EP 3 453 708 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
22.12.2021 Bulletin 2021/51

(45) Mention of the grant of the patent:
27.10.2021 Bulletin 2021/43

(21) Application number: 18186197.2

(22) Date of filing: 15.12.2011
(51) International Patent Classification (IPC): 
C07D 401/12(2006.01)
A61P 35/00(2006.01)
 A61K 31/506(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; A61P 43/00; A61P 35/02; C07D 403/12; C07D 401/12; A61K 31/506

(54)

PROCESS FOR THE PREPARATION OF 5-CHLORO-N2-(2-ISOPROPOXY-5-METHYL-4-PIPERIDIN-4-YL-PHENYL)-N-4-(2-(PROPAND-2-SULFONYL)-PHENYL)-PYRIMIDINE-2,4-DIAMINE DI-HYDROCHLORIDE

VERFAHREN FÜR DIE HERSTELLUNG VON 5-CHLOR-N2-(2-ISOPROPOXY-5-METHYL-4-PIPERIDIN-4-YL-PHENYL)-N-4-(2-(PROPAND-2-SULFONYL)PHENYL)-PYRIMIDINE-2,4-DIAMINE DI-HYDROCHLORIDE

PROCÉDÉ POUR LA PRÉPARATION DE 5-CHLORO-N2-(2-ISOPROPOXY-5-METHYL-4-PIPERIDIN-4-YL-PHENYL)-N-4-(2-(PROPAND-2-SULFONYL)PHENYL)-PYRIMIDINE-2,4-DIAMINE DI-HYDROCHLORIDE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 17.12.2010 US 201061424194 P

(43) Date of publication of application:
13.03.2019 Bulletin 2019/11

(62) Application number of the earlier application in accordance with Art. 76 EPC:
16167355.3 / 3121171
11806079.7 / 2651918

(73) Proprietor: Novartis AG
4056 Basel (CH)

(72) Inventors:
  • FENG, Lili
    East Hanover, New Jersey 07936-1080 (US)
  • GONG, Baoqing
    East Hanover, New Jersey 07936-1080 (US)
  • KARPINSKI, Piotr H.
    East Hanover, New Jersey 07936-1080 (US)
  • WAYKOLE, Liladhar Murlidhar
    East Hanover, New Jersey 07936-1080 (US)

(74) Representative: Kristl, Jernej 
Novartis Pharma AG Patent Department
4002 Basel
4002 Basel (CH)


(56) References cited: : 
WO-A2-2008/073687
   
       
    Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).