| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
|
Designated Extension States: |
|
BA ME |
| (30) |
Priority: |
07.12.2012 US 201261734941 P
15.03.2013 US 201361799069 P
15.03.2013 US 201313841711
05.11.2013 US 201361900347 P
|
| (43) |
Date of publication of application: |
|
20.03.2019 Bulletin 2019/12 |
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
13861008.4 / 2928477 |
| (73) |
Proprietor: Geron Corporation |
|
Foster City, CA 94404 (US) |
|
| (72) |
Inventors: |
|
- STUART, Monic, J.
Hillsborough, CA 94010 (US)
- KELSEY, Stephen
Palo Alto, CA 94301 (US)
|
| (74) |
Representative: Bassil, Nicholas Charles |
|
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL
London WC1X 8NL (GB) |
| (56) |
References cited: :
CN-A- 101 220 044
|
US-A1- 2005 282 893
|
|
| |
|
|
- GABRIELA M BAERLOCHER ET AL: "Imetelstat Rapidly Induces and Maintains Substantial
Hematologic and Molecular Responses in Patients with Essential Thrombocythemia (ET)
Who Are Refractory or Intolerant to Prior Therapy: Preliminary Phase II Results",
ANNUAL MEETING OF THE AM SOCIETY, vol. 120, no. 21, 16 November 2012 (2012-11-16),
pages 1-16, XP055254428,
- KAKIUCHI YASUTAKA ET AL: "Inhibition of Human Tumor Cell Proliferation by the Telomerase
Inhibitor TELIN", CYTOLOGIA (TOKYO), vol. 75, no. 2, June 2010 (2010-06), pages 177-183,
XP008180568, ISSN: 0011-4545
- TAUCHI TETSUZO ET AL: "Activity of a novel G-quadruplex-interactive telomerase inhibitor,
SOT-095, against human leukemia cells: Involvement of ATM-dependent DNA damage response
pathways", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US , vol. 102, no. 11 16 November
2003 (2003-11-16), page 652a, XP008180575, ISSN: 0006-4971 Retrieved from the Internet:
URL:http://www.bloodjournal.org/
- BAERLOCHER GABRIELA M ET AL: "Imetelstat Rapidly Induces and Maintains Substantial
Hematologic and Molecular Responses in Patients with Essential Thrombocythemia (ET)
Who Are Refractory or Intolerant to Prior Therapy: Preliminary Phase II Results",
BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US , vol. 120, no. 21 1 November 2012 (2012-11-01),
page 179, XP008180577, ISSN: 0006-4971 Retrieved from the Internet: URL:http://www.bloodjournal.org/
- CLAUDIO BRUNOLD ET AL: "3843: Imetelstat, A Potent Telomerase Inhibitor, Inhibits
the Spontaneous Growth of CFU-Meg In Vitro From Essential Thrombocythemia Patients
but Not From Healthy Individuals", BLOOD, vol. 118, no. 21, 18 November 2011 (2011-11-18),
- 13 December 2011 (2011-12-13), page 3843, XP055254840, US ISSN: 0006-4971
- CATENACCI ET AL: "Myelodysplasic syndromes: A comprehensive review", BLOOD REVIEWS,
CHURCHILL LIVINGSTONE, AMSTERDAM, NL, vol. 19, no. 6, 1 November 2005 (2005-11-01),
pages 301-319, XP005167052, ISSN: 0268-960X, DOI: 10.1016/J.BLRE.2005.01.004
- FENAUX ET AL (POSTER 4256) ASH (2017): POSTER, 2017,
- STEENSMA ET AL (ABSTRACT 463) ASH (2018): ASH ORAL PRESENTATION, 2018,
- STEENSMA ET AL (ABSTRACT S1557) EHA (2018): EUROPEAN HEMATOLOGY ASSOCIATION, 2018,
|
|
