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EP 3 456 827 A3

(12)	EUROPEAN PATENT APPLICATION

(88) Date of publication A3: 08.05.2019 Bulletin 2019/19 (43) Date of publication A2: 20.03.2019 Bulletin 2019/12 (21) Application number: 18187720.0 (22) Date of filing: 02.06.2011

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) C07K 14/78(2006.01) C07K 14/495(2006.01) A61K 31/7088(2006.01) C07K 14/47(2006.01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 02.06.2010 US 350829 P 06.08.2010 US 371481 P 29.10.2010 US 408271 P (62) Application number of the earlier application in accordance with Art. 76 EPC: 11790388.0 / 2576579 (71) Applicant: Alnylam Pharmaceuticals, Inc. Cambridge, MA 02142 (US)

(72) Inventors: Hinkle, Gregory Cambridge, MA 02142 (US) Kotelianski, Victor Cambridge, MA 02142 (US) Bettencourt, Brian Cambridge, MA 02142 (US) Sehgal, Alfica Cambridge, MA 02142 (US) Novobrantseva, Tatiana Cambridge, MA 02142 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)