(19)

(11)

EP 3 468 634 A1

(12)

(43) Date of publication: 17.04.2019 Bulletin 2019/16 (21) Application number: 17772106.5 (22) Date of filing: 31.08.2017

(51) International Patent Classification (IPC):  A61M 1/00(2006.01) G01L 9/00(2006.01) (86) International application number: PCT/IB2017/055243 (87) International publication number: WO 2018/042366 (08.03.2018 Gazette 2018/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 01.09.2016 US 201662382351 P (71) Applicant: Novartis AG 4056 Basel (CH)	(72) Inventors: EKVALL, Johan Lake Forest, California 92630 (US) ESSEX, Paul J. Lake Forest, California 92630 (US) TODD, Kirk Lake Forest, California 92630 (US) (74) Representative: Hanna Moore + Curley  Garryard House 25/26 Earlsfort Terrace Dublin 2, D02 PX51 Dublin 2, D02 PX51 (IE)