                               SEQUENCE LISTING

<110> ELEVEN BIOTHERAPEUTICS, INC.
 
<120> CHIMERIC IL-1 RECEPTOR TYPE I AGONISTS AND ANTAGONISTS

<130> P40335EP-D1-PCT

<140> EP11749612.5
<141> 2011-07-29

<150> US 61/493,966
<151> 2011-06-06

<150> US 61/493,967
<151> 2011-06-06

<150> US 61/436,184
<151> 2011-01-25

<150> US 61/436,178
<151> 2011-01-25

<150> US 61/368,799
<151> 2010-07-29

<160> 58    

<170> PatentIn version 3.5

<210> 1
<211> 153
<212> PRT
<213> Homo sapiens

<400> 1
Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln Gln Lys 
1               5                   10                  15      


Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His Leu Gln 
            20                  25                  30          


Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala Glu 
        115                 120                 125             


Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Thr Met Gln Phe Val Ser Ser 
145                 150             


<210> 2
<211> 159
<212> PRT
<213> Homo sapiens

<400> 2
Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
1               5                   10                  15      


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
            20                  25                  30          


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
        35                  40                  45              


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
    50                  55                  60                  


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
65                  70                  75                  80  


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
                85                  90                  95      


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
            100                 105                 110         


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
        115                 120                 125             


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
    130                 135                 140                 


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
145                 150                 155                 


<210> 3
<211> 151
<212> PRT
<213> Homo sapiens

<400> 3
Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp 
145                 150     


<210> 4
<211> 160
<212> PRT
<213> Homo sapiens

<400> 4
Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu 
1               5                   10                  15      


Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser 
            20                  25                  30          


Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys 
        35                  40                  45              


Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly 
    50                  55                  60                  


Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys 
65                  70                  75                  80  


Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His 
                85                  90                  95      


Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn 
            100                 105                 110         


Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val 
        115                 120                 125             


Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser 
    130                 135                 140                 


Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
145                 150                 155                 160 


<210> 5
<211> 154
<212> PRT
<213> Homo sapiens

<400> 5
Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu Lys 
1               5                   10                  15      


Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His Ala 
            20                  25                  30          


Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg Trp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly Ser 
    50                  55                  60                  


Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu Glu 
65                  70                  75                  80  


Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys Ser 
                85                  90                  95      


Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu Ser 
            100                 105                 110         


Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp Gln 
        115                 120                 125             


Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala Pro 
    130                 135                 140                 


Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
145                 150                 


<210> 6
<211> 158
<212> PRT
<213> Homo sapiens

<400> 6
Met Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln 
1               5                   10                  15      


Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala 
            20                  25                  30          


Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser 
        35                  40                  45              


Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr 
    50                  55                  60                  


Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly 
65                  70                  75                  80  


Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr 
                85                  90                  95      


Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser 
            100                 105                 110         


Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile 
        115                 120                 125             


Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu 
    130                 135                 140                 


Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155             


<210> 7
<211> 157
<212> PRT
<213> Homo sapiens

<400> 7
Met Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
1               5                   10                  15      


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
            20                  25                  30          


Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys 
        35                  40                  45              


Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu 
    50                  55                  60                  


Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly 
65                  70                  75                  80  


Lys Pro Thr Leu Gln Leu Lys Glu Lys Asn Ile Met Asp Leu Tyr Val 
                85                  90                  95      


Glu Lys Lys Ala Gln Lys Pro Phe Leu Phe Phe His Asn Lys Glu Gly 
            100                 105                 110         


Ser Thr Ser Val Phe Gln Ser Val Ser Tyr Pro Gly Trp Phe Ile Ala 
        115                 120                 125             


Thr Ser Thr Thr Ser Gly Gln Pro Ile Phe Leu Thr Lys Glu Arg Gly 
    130                 135                 140                 


Ile Thr Asn Asn Thr Asn Phe Tyr Leu Asp Ser Val Glu 
145                 150                 155         


<210> 8
<211> 169
<212> PRT
<213> Homo sapiens

<400> 8
Met Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val Tyr 
1               5                   10                  15      


Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln 
            20                  25                  30          


Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser 
        35                  40                  45              


Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro 
    50                  55                  60                  


Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln 
65                  70                  75                  80  


Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr 
                85                  90                  95      


Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu 
            100                 105                 110         


Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser 
        115                 120                 125             


Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys 
    130                 135                 140                 


Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn 
145                 150                 155                 160 


Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 


<210> 9
<211> 25
<212> PRT
<213> Homo sapiens

<400> 9
Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
1               5                   10                  15      


Ala Gly Tyr Leu Gln Gly Pro Asn Val 
            20                  25  


<210> 10
<211> 5
<212> PRT
<213> Homo sapiens

<400> 10
Asn Leu Glu Glu Lys 
1               5   


<210> 11
<211> 32
<212> PRT
<213> Homo sapiens

<400> 11
Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln 
1               5                   10                  15      


Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys 
            20                  25                  30          


<210> 12
<211> 7
<212> PRT
<213> Homo sapiens

<400> 12
Ala Met Glu Ala Asp Gln Pro 
1               5           


<210> 13
<211> 28
<212> PRT
<213> Homo sapiens

<400> 13
Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
1               5                   10                  15      


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr 
            20                  25              


<210> 14
<211> 10
<212> PRT
<213> Homo sapiens

<400> 14
Val Gln Gly Glu Glu Ser Asn Asp Lys Ile 
1               5                   10  


<210> 15
<211> 8
<212> PRT
<213> Homo sapiens

<400> 15
Lys Lys Lys Met Glu Lys Arg Phe 
1               5               


<210> 16
<211> 73
<212> PRT
<213> Homo sapiens

<400> 16
Phe Ser Met Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro 
1               5                   10                  15      


Val Ala Leu Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu 
            20                  25                  30          


Lys Asp Asp Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn 
        35                  40                  45              


Tyr Pro Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu 
    50                  55                  60                  


Ile Asn Asn Lys Leu Glu Phe Glu Ser 
65                  70              


<210> 17
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 17
Ala Pro Val Arg Ser Leu Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Met Gln Phe Val Ser Ser 
145                 150             


<210> 18
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 18
Ala Pro Val Arg Ser Leu Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Ile His Gly Gly 
    50                  55                  60                  


Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 
65                  70                  75                  80  


Leu Glu Ala Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Met Gln Phe Val Ser Ser 
145                 150             


<210> 19
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 19
Ala Pro Val Arg Ser Leu Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Thr Met Gln Phe Val Ser Ser 
145                 150             


<210> 20
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 20
Ala Pro Val Arg Ser Leu Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Thr Met Gln Phe Val Ser Ser 
145                 150             


<210> 21
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 21
Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Met Gln Phe Val Ser Ser 
145                 150             


<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide

<400> 22
Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210> 23
<211> 152
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide

<400> 23
Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Glu Gln Gln Val Val Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile Thr Asp 
    130                 135                 140                 


Phe Thr Met Gln Phe Val Ser Ser 
145                 150         


<210> 24
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 24
Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Thr Met Gln Phe Val Ser Ser 
145                 150             


<210> 25
<211> 459
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic polynucleotide

<400> 25
gcacctgtac gatcactggc cttcagaatc tgggatgtta accagaagac cttctatctg       60

aggaacaacc aactagttgc tggatacttg caaggaccaa atgtcaattt agaagaaaag      120

atagatgtgt cctttgtaca aggagaagaa agtaatgaca aaatacctgt ggccttgggc      180

atccatggag ggaagatgtg cctgtcctgt gtcaagtctg gtgatgagac cagactccag      240

ctggaggcag ttgatcccaa aaattaccca aagaagaaga tggacaagcg cttcgccttc      300

atccgctcag acagcggccc caccaccagt tttgagtctg ccgcctgccc cggttggttc      360

ctctgcacag cgatggaagc tgaccagccc gtcagcctca ccaatatgcc tgacgaaggc      420

gtcatggtca ccaaattcta catgcaattt gtgtcttcc                             459


<210> 26
<211> 459
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic polynucleotide

<400> 26
gcacctgtac gatcactggc cttcagaatc tgggatgtta accagaagac cttctatctg       60

aggaacaacc aactagttgc tggatacttg caaggaccaa atgtcaattt agaagaaaag      120

atagatgtgt cctttgtaca aggagaagaa agtaatgaca aaatacctgt ggccttgggc      180

atccatggag ggaagatgtg cctgtcctgt gtcaagtctg gtgatgagac cagactccag      240

ctggaggcag ttgatcccaa aaattaccca aagaagaaga tggaaaagcg atttgtcttc      300

aacaagatag aaatcaataa caagctgagt tttgagtctg ccgcctgccc cggttggttc      360

ctctgcacag cgatggaagc tgaccagccc gtcagcctca ccaatatgcc tgacgaaggc      420

gtcatggtca ccaaattcta catgcaattt gtgtcttcc                             459


<210> 27
<211> 459
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic polynucleotide

<400> 27
gcacctgtac gatcactggc cttcagaatc tgggatgtta accagaagac cttctatctg       60

aggaacaacc aactagttgc tggatacttg caaggaccaa atgtcaattt agaagaaaag      120

ttctccatgt cctttgtaca aggagaagaa agtaatgaca aaatacctgt ggccttgggc      180

ctcaaggaaa agaatctgta cctgtcctgc gtgttgaaag atgataagcc cactctacag      240

ctggagagtg tagatcccaa aaattaccca aagaagaaga tggaaaagcg atttgtcttc      300

atccgctcag acagcggccc caccaccagt tttgagtctg ccgcctgccc cggttggttc      360

ctctgcacag cgatggaagc tgaccagccc gtcagcctca ccaatatgcc tgacgaaggc      420

gtcatggtca ccaaattcac catgcaattt gtgtcttcc                             459


<210> 28
<211> 459
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic polynucleotide

<400> 28
gcacctgtac gatcactggc cttcagaatc tgggatgtta accagaagac cttctatctg       60

aggaacaacc aactagttgc tggatacttg caaggaccaa atgtcaattt agaagaaaag      120

ttctccatgt cctttgtaca aggagaagaa agtaatgaca aaatacctgt ggccttgggc      180

ctcaaggaaa agaatctgta cctgtcctgc gtgttgaaag atgataagcc cactctacag      240

ctggagagtg tagatcccaa aaattaccca aagaagaaga tggaaaagcg atttgtcttc      300

aacaagatag aaatcaataa caagctggaa tttgagtctg ccgcctgccc cggttggttc      360

ctctgcacag cgatggaagc tgaccagccc gtcagcctca ccaatatgcc tgacgaaggc      420

gtcatggtca ccaaattcac catgcaattt gtgtcttcc                             459


<210> 29
<211> 459
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic polynucleotide

<400> 29
gcacctgtac gatcactgaa ctgcagaatc tgggatgtta accagaagac cttctatctg       60

aggaacaacc aactagttgc tggatacttg caaggaccaa atgtcaattt agaagaaaag      120

ttctccatgt cctttgtaca aggagaagaa agtaatgaca aaatacctgt ggccttgggc      180

ctcaaggaaa agaatctgta cctgtcctgc gtgttgaaag atgataagcc cactctacag      240

ctggagagtg tagatcccaa aaattaccca aagaagaaga tggaaaagcg atttgtcttc      300

aacaagatag aaatcaataa caagctggaa tttgagtctg cccagttccc caactggttc      360

ctctgcacag cgatggaagc tgaccagccc gtcagcctca ccaatatgcc tgacgaaggc      420

gtcatggtca ccaaattcta catgcaattt gtgtcttcc                             459


<210> 30
<211> 456
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic polynucleotide

<400> 30
gcacctgtac gatcactgaa ctgcacgctc tgggatgtta accagaagac cttctatctg       60

aggaacaacc aactagttgc tggatacttg caaggaccaa atgtcgagca acaagtggtg      120

ttctccatgt cctttgtaca aggagaagaa agtaatgaca aaatacctgt ggccttgggc      180

ctcaaggaaa agaatctgta cctgtcctgc gtgttgaaag atgataagcc cactctacag      240

ctggagagtg tagatcccaa aaattaccca aagaagaaga tggaaaagcg atttgtcttc      300

aacaagatag aaatcaataa caagctggaa tttgagtctg cccagttccc caactggtac      360

atcagcacct ctatggaagc tgaccagccc gtcttcctgg gagggaccaa aggcggccag      420

gatataactg acttcaccat gcaatttgtg tcttcc                                456


<210> 31
<211> 459
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic polynucleotide

<400> 31
gcacctgtac gatcactgaa ctgcagaatc tgggatgtta accagaagac cttctatctg       60

aggaacaacc aactagttgc tggatacttg caaggaccaa atgtcaattt agaagaaaag      120

ttctccatgt cctttgtaca aggagaagaa agtaatgaca aaatacctgt ggccttgggc      180

ctcaaggaaa agaatctgta cctgtcctgc gtgttgaaag atgataagcc cactctacag      240

ctggagagtg tagatcccaa aaattaccca aagaagaaga tggaaaagcg atttgtcttc      300

aacaagatag aaatcaataa caagctggaa tttgagtctg cccagttccc caactggttc      360

ctctgcacag cgatggaagc tgaccagccc gtcagcctca ccaatatgcc tgacgaaggc      420

caggatataa ctgacttcac catgcaattt gtgtcttcc                             459


<210> 32
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 32
Ala Pro Val Arg Ser Leu Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Met Gln Phe Val Ser Ser 
145                 150             


<210> 33
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 33
Ala Pro Val Arg Ser Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Met Gln Phe Val Ser Ser 
145                 150             


<210> 34
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 34
Ala Pro Val Arg Ser Leu Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Met Gln Phe Val Ser Ser 
145                 150             


<210> 35
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 35
Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Met Gln Phe Val Ser Ser 
145                 150             


<210> 36
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 36
Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Thr Met Gln Phe Val Ser Ser 
145                 150             


<210> 37
<211> 151
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 37
Ala Pro Val Arg Ser Leu Ala Phe Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp 
145                 150     


<210> 38
<211> 151
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 38
Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp 
145                 150     


<210> 39
<211> 165
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 39
Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
1               5                   10                  15      


Ile Ile Lys Tyr Glu Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
            20                  25                  30          


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
        35                  40                  45              


Val Asn Leu Glu Glu Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys 
    50                  55                  60                  


Asp Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu 
65                  70                  75                  80  


Tyr Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met 
                85                  90                  95      


Pro Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe 
            100                 105                 110         


Phe Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His 
        115                 120                 125             


Pro Asn Leu Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
    130                 135                 140                 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Ile 
145                 150                 155                 160 


Leu Glu Asn Gln Ala 
                165 


<210> 40
<211> 160
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 40
Asp Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro 
1               5                   10                  15      


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn 
            20                  25                  30          


Asn Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys 
        35                  40                  45              


Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp 
    50                  55                  60                  


Glu Gly Val Met Val Thr Lys Phe Tyr Met Gln Phe Val Ser Ser Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Ser Ala Pro Val Arg Ser Leu Asn Cys Arg Ile 
                85                  90                  95      


Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 
            100                 105                 110         


Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Phe Ser 
        115                 120                 125             


Met Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala 
    130                 135                 140                 


Leu Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp 
145                 150                 155                 160 


<210> 41
<211> 160
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 41
Asn Tyr Pro Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile 
1               5                   10                  15      


Glu Ile Asn Asn Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp 
            20                  25                  30          


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
        35                  40                  45              


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Met Gln Phe Val 
    50                  55                  60                  


Ser Ser Gly Gly Ser Gly Gly Gly Ser Ala Pro Val Arg Ser Leu Asn 
65                  70                  75                  80  


Cys Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn 
                85                  90                  95      


Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu 
            100                 105                 110         


Lys Phe Ser Met Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile 
        115                 120                 125             


Pro Val Ala Leu Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val 
    130                 135                 140                 


Leu Lys Asp Asp Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys 
145                 150                 155                 160 


<210> 42
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic 6xHis tag

<400> 42
His His His His His His 
1               5       


<210> 43
<211> 7
<212> PRT
<213> Homo sapiens

<400> 43
Tyr Leu Gln Gly Pro Asn Val 
1               5           


<210> 44
<211> 8
<212> PRT
<213> Homo sapiens

<400> 44
Met Glu Ala Asp Gln Pro Val Ser 
1               5               


<210> 45
<211> 6
<212> PRT
<213> Homo sapiens

<400> 45
Arg Ser Leu Ala Phe Arg 
1               5       


<210> 46
<211> 6
<212> PRT
<213> Homo sapiens

<400> 46
Ile Asp Val Ser Phe Val 
1               5       


<210> 47
<211> 6
<212> PRT
<213> Homo sapiens

<400> 47
Lys Lys Met Asp Lys Arg 
1               5       


<210> 48
<211> 6
<212> PRT
<213> Homo sapiens

<400> 48
Lys Phe Tyr Met Gln Phe 
1               5       


<210> 49
<211> 6
<212> PRT
<213> Homo sapiens

<400> 49
Asn Lys Leu Ser Phe Glu 
1               5       


<210> 50
<211> 6
<212> PRT
<213> Homo sapiens

<400> 50
Glu Glu Lys Phe Ser Met 
1               5       


<210> 51
<211> 6
<212> PRT
<213> Homo sapiens

<400> 51
Arg Phe Val Phe Ile Arg 
1               5       


<210> 52
<211> 6
<212> PRT
<213> Homo sapiens

<400> 52
Val Thr Lys Phe Thr Met 
1               5       


<210> 53
<211> 6
<212> PRT
<213> Homo sapiens

<400> 53
Phe Glu Ser Ala Ala Cys 
1               5       


<210> 54
<211> 6
<212> PRT
<213> Homo sapiens

<400> 54
Val Thr Lys Phe Thr Met 
1               5       


<210> 55
<211> 6
<212> PRT
<213> Homo sapiens

<400> 55
Leu Asn Cys Arg Ile Trp 
1               5       


<210> 56
<211> 6
<212> PRT
<213> Homo sapiens

<400> 56
Pro Asn Trp Phe Leu Cys 
1               5       


<210> 57
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide consensus sequence


<220>
<221> Variant
<222> (2)..(3)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (6)..(13)
<223> Xaa can be any amino acid 

<220>
<221> misc_feature
<222> (14)..(14)
<223> Xaa can be any amino acid or absent 

<220>
<221> Variant
<222> (17)..(18)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (22)..(39)
<223> Xaa can be any amino acid 

<220>
<221> misc_feature
<222> (40)..(49)
<223> Xaa can be any amino acid or absent

<220>
<221> Variant
<222> (52)..(58)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (63)..(65)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (67)..(69)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (74)..(74)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (76)..(83)
<223> Xaa can be any amino acid 

<220>
<221> misc_feature
<222> (84)..(84)
<223> Xaa can be any amino acid or absent

<220>
<221> Variant
<222> (86)..(87)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (91)..(91)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (93)..(102)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (107)..(108)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (110)..(110)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (112)..(114)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (116)..(121)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (124)..(124)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (126)..(130)
<223> Xaa can be any amino acid 

<220>
<221> misc_feature
<222> (131)..(131)
<223> Xaa can be any amino acid or absent 

<220>
<221> Variant
<222> (133)..(135)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (137)..(137)
<223> Xaa can be any amino acid

<220>
<221> Variant
<222> (139)..(140)
<223> Xaa can be any amino acid

<400> 57
Asp Xaa Xaa Gln Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Ala 
1               5                   10                  15      


Xaa Xaa Leu Gln Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Leu Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Ser Cys Val Xaa Xaa 
    50                  55                  60                  


Xaa Asp Xaa Xaa Xaa Leu Gln Leu Glu Xaa Val Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Lys Xaa Xaa Lys Arg Phe Xaa Phe Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Phe Glu Ser Ala Xaa Xaa Pro Xaa Trp Xaa 
            100                 105                 110         


Xaa Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Pro Val Xaa Leu Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Gly Xaa Xaa Xaa Thr Xaa Phe Xaa Xaa Gln 
    130                 135                 140     


<210> 58
<211> 5
<212> PRT
<213> Homo sapiens

<400> 58
Ala Pro Val Arg Ser 
1               5   


