(19)

(11)

EP 3 472 309 A2

(12)

(88) Date of publication A3: 18.01.2018 (43) Date of publication: 24.04.2019 Bulletin 2019/17 (21) Application number: 17814218.8 (22) Date of filing: 16.06.2017

(51) International Patent Classification (IPC):  C12N 9/10(2006.01) C12P 7/42(2006.01) C12P 7/22(2006.01) (86) International application number: PCT/US2017/037995 (87) International publication number: WO 2017/218967 (21.12.2017 Gazette 2017/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 16.06.2016 US 201662351117 P (71) Applicant: Arkansas State University-Jonesboro State University, Arkansas 72467 (US)	(72) Inventors: MEDINA-BOLIVAR, Luis, Fabricio Bloomington, IN 47405 (US) YANG, Tianhong Bloomington, IN 47405 (US) MOCKAITIS, Keithanne Bloomington, IN 47405 (US) (74) Representative: Murgitroyd & Company  Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)