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(11)

EP 3 474 910 A1

(12)

(43) Date of publication: 01.05.2019 Bulletin 2019/18 (21) Application number: 17758264.0 (22) Date of filing: 21.06.2017

(51) International Patent Classification (IPC):  A61L 27/16(2006.01) A61F 2/16(2006.01) A61L 27/52(2006.01) (86) International application number: PCT/IB2017/000911 (87) International publication number: WO 2017/221068 (28.12.2017 Gazette 2017/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 23.06.2016 US 201615190715 (71) Applicant: Medicem Institute s.r.o. 273 011 Kamenné Zehrovice (CZ)	(72) Inventors: STOY, Vladimir Tuchomerice 25267 (CZ) PETRAK, Vaclav Kladno 27201 (CZ) DUDIC, Miroslav Krc 14200 (CZ) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)