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EP 3 475 435 A1

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(43) Date of publication: 01.05.2019 Bulletin 2019/18 (21) Application number: 17814828.4 (22) Date of filing: 23.06.2017

(51) International Patent Classification (IPC):  C12N 15/861(2006.01) A61K 39/00(2006.01) A61P 37/04(2006.01) C12N 15/34(2006.01) C12N 7/01(2006.01) A61K 35/76(2015.01) A61K 48/00(2006.01) C07K 14/075(2006.01) C12N 5/10(2006.01) (86) International application number: PCT/IB2017/000959 (87) International publication number: WO 2017/221075 (28.12.2017 Gazette 2017/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 24.06.2016 US 201662354639 P (71) Applicant: University of Saskatchewan Saskatoon, SK S7N 5A2 (CA)	(72) Inventors: TIKOO, Suresh, K. Saskatoon, SK S7V 1G6 (CA) ZHAO, Xin Saskatoon, SK S7N 5A2 (CA) (74) Representative: J A Kemp  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)