(19)
(11) EP 3 476 831 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
29.12.2021 Bulletin 2021/52

(45) Mention of the grant of the patent:
17.11.2021 Bulletin 2021/46

(21) Application number: 17814732.8

(22) Date of filing: 22.06.2017
(51) International Patent Classification (IPC): 
C07D 209/02(2006.01)
A61P 31/00(2006.01)
A61P 35/00(2006.01)
 A61K 31/65(2006.01)
A61P 31/04(2006.01)
A61P 3/10(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 31/00; A61P 3/10; A61P 31/04; A61P 35/00; C07D 209/02; A61K 31/65
(86) International application number:
PCT/CN2017/089470
(87) International publication number:
WO 2017/219994 (28.12.2017 Gazette 2017/52)

(54)

CRYSTAL FORM OF 9-AMINOMETHYL SUBSTITUTED TETRACYCLINE COMPOUNDS AND PREPARATION METHOD THEREFOR

KRISTALLFORM EINES 9-AMINOMETHYL-SUBSITUIERTEN TETRACYCLINVERBINDUNGEN UND HERSTELLUNGSVERFAHREN DAFÜR

FORME CRISTALLINE DE 9-AMINOMÉTHYLE SUBSTITUÉS DES COMPOSÉS DE TETRACYCLINE ET LEUR PROCÉDÉ DE PRÉPARATION

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD

(30) Priority: 22.06.2016 CN 201610457261

(43) Date of publication of application:
01.05.2019 Bulletin 2019/18

(73) Proprietor: KBP BIOSCIENCES PTE. LTD.
Singapore 068898 (SG)

(72) Inventors:
  • HUANG, Zhenhua
    Jinan, Shandong 250101 (CN)
  • HONG, Mei
    Jinan, Shandong 250101 (CN)
  • JIANG, Chen
    Jinan, Shandong 250101 (CN)

(74) Representative: Croce, Valeria 
Jacobacci & Partners S.p.A. Via Senato, 8
20121 Milano
20121 Milano (IT)


(56) References cited: : 
EP-A1- 2 738 156
CN-B- 103 717 571
 CN-A- 102 417 465
   
  • YU L ED - KWON ICK CHAN ET AL: "AMORPHOUS PHARMACEUTICAL SOLIDS: PREPARATION, CHARACTERIZATION AND STABILIZATION", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 1, 16 May 2001 (2001-05-16), pages 27-42, XP009065056, ISSN: 0169-409X, DOI: 10.1016/S0169-409X(01)00098-9
  • MINO R CAIRA ED - MONTCHAMP JEAN-LUC: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY; [TOPICS IN CURRENT CHEMISTRY], SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163-208, XP001156954, ISSN: 0340-1022, DOI: 10.1007/3-540-69178-2_5 [retrieved on 1999-02-26]
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).