(19)

(11)

EP 3 478 316 A1

(12)

(43) Date of publication: 08.05.2019 Bulletin 2019/19 (21) Application number: 17821442.5 (22) Date of filing: 03.07.2017

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) A61P 37/04(2006.01) A61K 31/74(2006.01) A61P 25/28(2006.01) (86) International application number: PCT/US2017/040598 (87) International publication number: WO 2018/006092 (04.01.2018 Gazette 2018/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 01.07.2016 US 201662357800 P 29.03.2017 US 201762478410 P (71) Applicant: Declion Holdings LLC Boxford, MA 01921 (US)	(72) Inventor: ZANELLI, Eric Sudbury MA 01776 (US) (74) Representative: Lock, Graham James  Fry Heath & Spence LLP Unit A, Faraday Court Faraday Road Crawley, West Sussex RH10 9PU Unit A, Faraday Court Faraday Road Crawley, West Sussex RH10 9PU (GB)