(19)

(11)

EP 3 487 507 A1

(12)

(43) Date of publication: 29.05.2019 Bulletin 2019/22 (21) Application number: 17831904.2 (22) Date of filing: 20.07.2017

(51) International Patent Classification (IPC):  A61K 31/7088(2006.01) C12N 15/00(2006.01) C12N 15/86(2006.01) A61K 35/76(2015.01) C12N 15/63(2006.01) (86) International application number: PCT/US2017/043157 (87) International publication number: WO 2018/017882 (25.01.2018 Gazette 2018/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 21.07.2016 US 201662365316 P (71) Applicant: American Gene Technologies International, Inc. Rockville, MD 20850 (US)	(72) Inventors: LAHUSEN, Tyler Rockville MA 20850 (US) PAUZA, Charles, David Rockville MA 20850 (US) (74) Representative: D Young & Co LLP  120 Holborn London EC1N 2DY London EC1N 2DY (GB)