(19)

(11)

EP 3 487 542 A1

(12)

(43) Date of publication: 29.05.2019 Bulletin 2019/22 (21) Application number: 17754818.7 (22) Date of filing: 21.07.2017

(51) International Patent Classification (IPC):  A61K 49/00(2006.01) C07K 14/47(2006.01) (86) International application number: PCT/NL2017/050497 (87) International publication number: WO 2018/016960 (25.01.2018 Gazette 2018/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 21.07.2016 EP 16180535 (71) Applicant: Academisch Ziekenhuis Leiden h.o.d.n. LUMC 2333 ZA Leiden (NL)	(72) Inventors: VAN LEEUWEN, Fijs Willem Bernhard 2333 ZA Leiden (NL) BUCKLE, Tessa 2333 ZA Leiden (NL) VAN WILLIGEN, Danny Michel 2333 ZA Leiden (NL) VAN DER WAL, Steffen 2333 ZA Leiden (NL) (74) Representative: V.O.  P.O. Box 87930 Carnegieplein 5 2508 DH Den Haag 2508 DH Den Haag (NL)