| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
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Designated Extension States: |
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BA ME |
| (30) |
Priority: |
20.07.2016 WO PCT/EP2016/067348
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| (43) |
Date of publication of application: |
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29.05.2019 Bulletin 2019/22 |
| (60) |
Divisional application: |
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21178672.8 |
| (73) |
Proprietor: BioNTech SE |
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55131 Mainz (DE) |
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| (72) |
Inventors: |
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- TADMOR, Arbel D.
55294 Bodenheim (DE)
- SAHIN, Ugur
55116 Mainz (DE)
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| (74) |
Representative: Schnappauf, Georg et al |
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ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München
80686 München (DE) |
| (56) |
References cited: :
WO-A1-2013/120509
WO-A2-2012/159754
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WO-A2-2011/143656
US-A1- 2015 331 992
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- TUERECI OEZLEM ET AL: "Targeting the Heterogeneity of Cancer with Individualized Neoepitope
Vaccines", CLINICAL CANCER RESEARCH, vol. 22, no. 8, April 2016 (2016-04), pages 1885-1896,
XP055300469, ISSN: 1078-0432
- CASTLE JOHN C ET AL: "Mutated tumor alleles are expressed according to their DNA frequency",
SCIENTIFIC REPORTS, vol. 4, April 2014 (2014-04), pages 1-6, XP002774681, ISSN: 2045-2322
- SCOTT L CARTER ET AL: "Absolute quantification of somatic DNA alterations in human
cancer", NATURE BIOTECHNOLOGY, vol. 30, no. 5, 1 January 2012 (2012-01-01), pages
413-421, XP055042894, ISSN: 1087-0156, DOI: 10.1038/nbt.2203
- MYHRE SIMEN ET AL: "Influence of DNA copy number and mRNA levels on the expression
of breast cancer related proteins", MOLECULAR ONCOLOGY, vol. 7, no. 3, June 2013 (2013-06),
pages 704-718, XP002777340, ISSN: 1574-7891
- GUNNARSSON CECILIA ET AL: "Amplification of HSD17B1 has prognostic significance in
postmenopausal breast cancer", BREAST CANCER RESEARCH AND TREATMENT, vol. 108, no.
1, March 2008 (2008-03), pages 35-41, XP002777341, ISSN: 0167-6806
- WANG TIM ET AL: "Identification and characterization of essential genes in the human
genome", HHS Public Access Author Manuscript , November 2015 (2015-11), pages 1-13,
XP002777395, Retrieved from the Internet: URL:https://www.ncbi.nlm.nih.gov/pmc/artic
les/PMC4662922/ [retrieved on 2018-01-18]
- CHIARI RITA ET AL: "Two antigens recognized by autologous cytolytic T lymphocytes
on a melanoma result from a single point mutation in an essential housekeeping gene",
CANCER RESEARCH, vol. 59, no. 22, 15 November 1999 (1999-11-15), pages 5785-5792,
XP055111371, ISSN: 0008-5472
|
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