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(11)

EP 3 504 328 A1

(12)

(43) Date of publication: 03.07.2019 Bulletin 2019/27 (21) Application number: 17798018.2 (22) Date of filing: 24.08.2017

(51) International Patent Classification (IPC):  C12N 9/20(2006.01) C12N 9/80(2006.01) C12N 9/18(2006.01) C07K 16/00(2006.01) (86) International application number: PCT/US2017/048498 (87) International publication number: WO 2018/039499 (01.03.2018 Gazette 2018/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 24.08.2016 US 201662379226 P (71) Applicant: Regeneron Pharmaceuticals, Inc. Tarrytown, NY 10591 (US)	(72) Inventors: CHEN, Gang Tarrytown, New York 10591 (US) LI, Ning Tarrytown, New York 10591 (US) GOREN, Michael Tarrytown, New York 10591 (US) BURAKOV, Darya Tarrytown, New York 10591 (US) LI, Chen Tarrytown, New York 10591 (US) (74) Representative: Wise, Daniel Joseph  Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA London WC1B 5HA (GB)