ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................*JBDM Ver 1.7.2 (20 November 2019) - 2999001/0The file contains technical information submitted after the application was filed and not included in this specification3507277CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120210303W173deBibliographieenBibliographyfrBibliographieEP17764971.22017082920190311enenen201662382132 P20160831US2021030320210920190710201928202011182020472020052920210303202109C07D 265/14 20060101AFI20180309BHEP A61K 31/537 20060101ALI20180309BHEP A61P 25/24 20060101ALI20180309BHEP deHYDROXYNORKETAMINDERIVATE ZUR BEHANDLUNG VON ERKRANKUNGENenHYDROXYNORKETAMINE DERIVATIVES FOR THE TREATMENT OF DISORDERSfrDÉRIVÉS D'HYDROXYNORKÉTAMINE POUR LE TRAITEMENT DES MALADIESWO-A1-2004/045601PANOS ZANOS ET AL: "NMDAR inhibition-independent antidepressant actions of ketamine metabolites", NATURE, vol. 533, no. 7604, 4 May 2016 (2016-05-04), pages 481-486, XP55368059, ISSN: 0028-0836, DOI: 10.1038/nature17998 cited in the applicationMOADDEL R ET AL: "A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 82, no. 5, 15 October 2010 (2010-10-15), pages 1892-1904, XP027338855, ISSN: 0039-9140 [retrieved on 2010-08-13] cited in the applicationJ. D. ADAMS ET AL: "Studies on the biotransformation of ketamine 1-Identification of metabolites producedin vitro from rat liver microsomal preparations", BIOLOGICAL MASS SPECTROMETRY, vol. 8, no. 11, 1 November 1981 (1981-11-01), pages 527-538, XP55048408, ISSN: 1052-9306, DOI: 10.1002/bms.1200081103PATRICK J. MORRIS ET AL: "-aspartate (NMDA) Receptor Activity of Ketamine Metabolites", ORGANIC LETTERS , 14(23), 6012-6015 CODEN: ORLEF7; ISSN: 1523-7052, vol. 19, no. 17, 22 August 2017 (2017-08-22), pages 4572-4575, XP055410503, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b02177GOMEZ, Laurentc/o Dart NeuroScience LLC 3811 Turtle Creek Blvd., Suite 975Dallas, TX 75219USMASSARI, Mark, Ebenc/o Dart NeuroScience LLC 3811 Turtle Creek Blvd., Suite 975Texas, TX 75219USDart NeuroScience, LLC101851862P075111EP3811 Turtle Creek Blvd. Suite 975Dallas, TX 75219USMcGuire, Gillian Margaret101250941Carpmaels & Ransford LLP One Southampton RowLondon WC1B 5HAGBALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTRUS201704912920170829enWO201804489620180308201810