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(11)

EP 3 512 502 A1

(12)

(43) Date of publication: 24.07.2019 Bulletin 2019/30 (21) Application number: 17780529.8 (22) Date of filing: 11.09.2017

(51) International Patent Classification (IPC):  A61K 9/12(2006.01) A61P 17/02(2006.01) A61K 47/42(2017.01) (86) International application number: PCT/IL2017/000007 (87) International publication number: WO 2018/051325 (22.03.2018 Gazette 2018/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 14.09.2016 IL 24781016 14.09.2016 US 201662394371 P (71) Applicants: Omrix Biopharmaceuticals Ltd. Rehovot 7610601 (IL) Ethicon, Inc. Somerville, NJ 08876 (US)	(72) Inventors: AUERBACH-NEVO, Tamar Rehovot 7630505 (IL) DEANGLIS, Ashley Skillman NJ 08558 (US) NUR, Israel Nes Ziona 7403769 (IL) (74) Representative: Kirsch, Susan Edith  Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA London WC1B 5HA (GB)