(19)
(11) EP 3 514 173 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
04.08.2021 Bulletin 2021/31

(45) Mention of the grant of the patent:
23.06.2021 Bulletin 2021/25

(21) Application number: 19156509.2

(22) Date of filing: 06.04.2010
(51) International Patent Classification (IPC): 
C07K 16/18(2006.01)
A61K 39/00(2006.01)

(54)

DKK-1 ANTIBODIES

DKK-1-ANTIKĂ–RPER

ANTICORPS CONTRE DKK-1


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated Extension States:
AL BA ME RS

(30) Priority: 10.04.2009 US 16841109 P

(43) Date of publication of application:
24.07.2019 Bulletin 2019/30

(62) Application number of the earlier application in accordance with Art. 76 EPC:
15159780.4 / 2930184
10712681.5 / 2417158

(73) Proprietor: ELI LILLY AND COMPANY
Indianapolis, IN 46285 (US)

(72) Inventors:
  • Chedid, Marcio
    Indianapolis, IN 46206-6288 (US)
  • Darling, Ryan James
    Indianapolis, IN 46206-6288 (US)
  • Galvin, Rachelle Jeanette
    Indianapolis, IN 46206-6288 (US)
  • Swanson, Barbara Anne
    Indianapolis, IN 46206-6288 (US)

(74) Representative: Kent, Lindsey Ruth 
Eli Lilly and Company Limited 8 Arlington Square West Downshire Way
Bracknell, Berkshire RG12 1PU
Bracknell, Berkshire RG12 1PU (GB)


(56) References cited: : 
WO-A1-2008/097510
WO-A2-2006/015373
WO-A1-2010/129752
WO-A2-2007/084344
   
  • FULCINITI MARIATERESA ET AL: "Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, UNITED STATES LNKD- DOI:10.1182/BLOOD-2008-11-191577, vol. 114, no. 2, 9 July 2009 (2009-07-09), pages 371-379, XP009134332, ISSN: 1528-0020 [retrieved on 2009-05-05]
  • GAVRIATOPOULOU MARIA ET AL: "Dickkopf-1: a suitable target for the management of myeloma bone disease.", EXPERT OPINION ON THERAPEUTIC TARGETS JUL 2009 LNKD- PUBMED:19530987, vol. 13, no. 7, July 2009 (2009-07), pages 839-848, XP009134320, ISSN: 1744-7631
  • YACCOBY SHMUEL ET AL: "Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US LNKD- DOI:10.1182/BLOOD-2006-09-047712, vol. 109, no. 5, 1 March 2007 (2007-03-01) , pages 2106-2111, XP002486200, ISSN: 0006-4971 [retrieved on 2006-10-26]
  • ETTENBERG SETH A ET AL: "BHQ880, a novel anti-DKK1 neutralizing antibody, inhibits tumor-induced osteolytic bone disease", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 49, 1 April 2008 (2008-04-01), page 947, XP009134334, ISSN: 0197-016X
  • HEATH DEBORAH J ET AL: "Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma", JOURNAL OF BONE AND MINERAL RESEARCH, AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH, NEW YORK, NY, US LNKD- DOI:10.1359/JBMR.081104, vol. 24, no. 3, 1 March 2009 (2009-03-01), pages 425-436, XP009134333, ISSN: 0884-0431 [retrieved on 2009-12-04]
  • FILIPPO CARACI ET AL: "The Wnt Antagonist, Dickkopf-1, as a Target for the Treatment of Neurodegenerative Disorders", NEUROCHEMICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE LNKD- DOI:10.1007/S11064-008-9710-0, vol. 33, no. 12, 22 April 2008 (2008-04-22), pages 2401-2406, XP019647587, ISSN: 1573-6903
  • HALL CHRISTOPHER L ET AL: "Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis", PROSTATE, WILEY-LISS, NEW YORK, NY, US LNKD- DOI:10.1002/PROS.20805, vol. 68, no. 13, 15 September 2008 (2008-09-15), pages 1396-1404, XP009134318, ISSN: 0270-4137 [retrieved on 2008-06-16]
  • TERPOS E: "Antibodies to dickkopf-1 protein", EXPERT OPINION ON THERAPEUTIC PATENTS, INFORMA HEALTHCARE, GB LNKD- DOI:10.1517/13543776.16.10.1453, vol. 16, no. 10, 1 October 2006 (2006-10-01), pages 1453-1458, XP002486202, ISSN: 1354-3776
  • ZHOU XIAO-LEI ET AL: "Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling", ACTA PHARMACOLOGICA SINICA, vol. 31, no. 2, February 2010 (2010-02), pages 202-210, XP009134321,
  • KRAJ MARIA: "Multiple myeloma bone disease and novel anti-myeloma agents", ACTA HAEMATOLOGICA POLONICA, vol. 39, no. 2, 2008, pages 163-178, XP009134337, ISSN: 0001-5814
  • DIARRA DANIELLE ET AL: "Dickkopf-1 is a master regulator of joint remodeling", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US LNKD- DOI:10.1038/NM1538, vol. 13, no. 2, 1 February 2007 (2007-02-01), pages 156-163, XP002486201, ISSN: 1078-8956 [retrieved on 2007-01-21]
  • MELODY MAZON ET AL: "Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?", CANCERS, vol. 8, no. 7, 28 June 2016 (2016-06-28), page 62, XP55329263, DOI: 10.3390/cancers8070062
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).