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(11)

EP 3 515 450 A1

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(43) Date of publication: 31.07.2019 Bulletin 2019/31 (21) Application number: 17853814.6 (22) Date of filing: 20.09.2017

(51) International Patent Classification (IPC):  A61K 31/57(2006.01) A61K 31/56(2006.01) C12N 5/071(2010.01) A61K 31/00(2006.01) C12N 5/00(2006.01) C12N 5/0735(2010.01) (86) International application number: PCT/US2017/052516 (87) International publication number: WO 2018/057624 (29.03.2018 Gazette 2018/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 21.09.2016 US 201615272098 (71) Applicant: Mount Desert Island Biological Laboratory Salisbury Cove, ME 04672 (US)	(72) Inventors: ZASLOFF, Michael Alan Merion PA 19066 (US) YIN, Viravuth Pho Trenton ME 04605 (US) STRANGE, Kevin B. Lamoine ME 04605 (US) (74) Representative: Boult Wade Tennant LLP  5th Floor, Salisbury Square House 8, Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)