| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
|
Designated Extension States: |
|
BA ME |
|
Designated Validation States: |
|
MA MD |
| (30) |
Priority: |
21.09.2016 US 201662397752 P
05.06.2017 US 201762515480 P
|
| (43) |
Date of publication of application: |
|
31.07.2019 Bulletin 2019/31 |
| (60) |
Divisional application: |
|
22179377.1 |
| (73) |
Proprietor: ALX Oncology Inc. |
|
South San Francisco, CA 94080 (US) |
|
| (72) |
Inventors: |
|
- PONS, Jaume
Burlingame, CA 94010 (US)
- SIM, Bang Janet
Burlingame, CA 94010 (US)
- WAN, Hong
Burlingame, CA 94010 (US)
- KUO, Tracy Chia-Chien
Burlingame, CA 94010 (US)
- KAUDER, Steven Elliot
Burlingame, CA 94010 (US)
- HARRIMAN, William Don
Emeryville, CA 94608-2059 (US)
- IZQUIERDO, Shelley
Emeryville, CA 94608-2059 (US)
|
| (74) |
Representative: J A Kemp LLP |
|
80 Turnmill Street
London EC1M 5QU
London EC1M 5QU (GB) |
| (56) |
References cited: :
WO-A1-2013/056352
WO-A1-2016/063233
US-A1- 2003 054 415
|
WO-A1-2016/063233
WO-A2-2015/138600
US-A1- 2003 054 415
|
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| |
|
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- SEIFFERT M ET AL: "HUMAN SIGNAL-REGULATORY PROTEIN IS EXPRESSED ON NORMAL, BUT NOT
ON SUBSETS OF LEUKEMIC MYELOID CELLS AND MEDIATES CELLULAR ADHESION INVOLVING ITS
COUNTERRECEPTOR CD47", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 94, no. 11,
1 December 1999 (1999-12-01), pages 3633-3643, XP000973562, ISSN: 0006-4971
- M. SEIFFERT: "Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved
in T-cell activation, binds to CD47 with high affinity, and is expressed on immature
CD34+CD38- hematopoietic cells", BLOOD, vol. 97, no. 9, 1 May 2001 (2001-05-01), pages
2741-2749, XP055056672, ISSN: 0006-4971, DOI: 10.1182/blood.V97.9.2741
- W. Y. LEE ET AL: "Novel Structural Determinants on SIRP that Mediate Binding to CD47",
THE JOURNAL OF IMMUNOLOGY, vol. 179, no. 11, 19 November 2007 (2007-11-19), pages
7741-7750, XP055497847, ISSN: 0022-1767, DOI: 10.4049/jimmunol.179.11.7741
- X. W. ZHAO ET AL: "CD47-signal regulatory protein-? (SIRP?) interactions form a barrier
for antibody-mediated tumor cell destruction", PROCEEDINGS OF THE NATIONAL ACADEMY
OF SCIENCES, vol. 108, no. 45, 8 November 2011 (2011-11-08), pages 18342-18347, XP055055636,
ISSN: 0027-8424, DOI: 10.1073/pnas.1106550108
- JOANNE E NETTLESHIP ET AL: "Crystal structure of signal regulatory protein gamma (SIRP[gamma])
in complex with an antibody Fab frag", BMC STRUCTURAL BIOLOGY, BIOMED CENTRAL LTD.,
LONDON, GB, vol. 13, no. 1, 4 July 2013 (2013-07-04), page 13, XP021156553, ISSN:
1472-6807, DOI: 10.1186/1472-6807-13-13
- SEIFFERT, M. ET AL.: 'Human Signal-Regulatory Protein Is Expressed on Normal, But
Not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving
Its Counterreceptor CD 47' BLOOD vol. 94, no. 11, 1999, pages 3633 - 3643, XP000973562
- SEIFFERT, M. ET AL.: 'Signal-regulatory protein a (SIRPa) but not SIRPb is involved
in T- cell activation, binds to CD 47 with high affinity, and is expressed on immature
CD 34+ CD 38- hematopoietic cells' BLOOD vol. 97, no. 9, pages 2741 - 2749, XP055056672
- LEE, W. ET AL.: 'Novel Structural Determinants on SIRPa that Mediate Binding to CD
47' THE JOURNAL OF IMMUNOLOGY vol. 179, 2007, pages 7741 - 7750, XP055497847
- ZHAO, X. ET AL.: 'CD 47-signal regulatory protein-a (SIRPa) interactions form a barrier
for antibody-mediated tumor cell destruction' PNAS USA vol. 108, no. 45, 2011, pages
18342 - 18347, XP055055636
- NETTLESHIP, J. ET AL.: 'Crystal structure of signal regulatory protein gamma (SIRPg)
in complex with an antibody Fab fragment' BMC STRUCTURAL BIOLOGY vol. 13, 2013, pages
1 - 8, XP021156553
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