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<ep-patent-document id="EP17853838B8W1" file="EP17853838W1B8.xml" lang="en" country="EP" doc-number="3515490" kind="B8" correction-code="W1" date-publ="20220914" status="c" dtd-version="ep-patent-document-v1-5-1">
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</text></classification-cpc><classification-cpc sequence="9"><text>C07K2317/76        20130101 LA20180419BHEP        </text></classification-cpc><classification-cpc sequence="10"><text>C07K2317/92        20130101 LA20180419BHEP        </text></classification-cpc><classification-cpc sequence="11"><text>C07K2317/23        20130101 LA20200120BHEP        </text></classification-cpc><classification-cpc sequence="12"><text>A61P   1/04        20180101 LI20200318BHEP        </text></classification-cpc><classification-cpc sequence="13"><text>A61P  11/00        20180101 LI20200318BHEP        </text></classification-cpc><classification-cpc sequence="14"><text>A61P  11/06        20180101 LI20200318BHEP        </text></classification-cpc><classification-cpc sequence="15"><text>A61P  13/12        20180101 LI20200319BHEP        </text></classification-cpc><classification-cpc sequence="16"><text>A61P  15/00        20180101 LI20200319BHEP        </text></classification-cpc><classification-cpc 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LI20200327BHEP        </text></classification-cpc><classification-cpc sequence="26"><text>A61P  35/00        20180101 LI20200327BHEP        </text></classification-cpc><classification-cpc sequence="27"><text>A61P   3/10        20180101 LI20200330BHEP        </text></classification-cpc><classification-cpc sequence="28"><text>A61P  37/00        20180101 LI20200331BHEP        </text></classification-cpc><classification-cpc sequence="29"><text>A61P  37/06        20180101 LI20200331BHEP        </text></classification-cpc><classification-cpc sequence="30"><text>A61P   9/00        20180101 LI20200331BHEP        </text></classification-cpc><classification-cpc sequence="31"><text>A61P   9/10        20180101 LI20200331BHEP        </text></classification-cpc></classifications-cpc></B520EP><B540><B541>de</B541><B542>ANTIKÖRPER GEGEN SIGNALREGULATORISCHES PROTEIN ALPHA UND VERFAHREN ZUR VERWENDUNG</B542><B541>en</B541><B542>ANTIBODIES AGAINST SIGNAL-REGULATORY PROTEIN ALPHA AND METHODS OF USE</B542><B541>fr</B541><B542>ANTICORPS CONTRE LA PROTÉINE RÉGULATRICE DE SIGNAL ALPHA ET PROCÉDÉS D'UTILISATION</B542></B540><B560><B561><text>WO-A1-2013/056352</text></B561><B561><text>WO-A1-2016/063233</text></B561><B561><text>WO-A1-2016/063233</text></B561><B561><text>WO-A2-2015/138600</text></B561><B561><text>US-A1- 2003 054 415</text></B561><B561><text>US-A1- 2003 054 415</text></B561><B562><text>SEIFFERT M ET AL: "HUMAN SIGNAL-REGULATORY PROTEIN IS EXPRESSED ON NORMAL, BUT NOT ON SUBSETS OF LEUKEMIC MYELOID CELLS AND MEDIATES CELLULAR ADHESION INVOLVING ITS COUNTERRECEPTOR CD47", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 94, no. 11, 1 December 1999 (1999-12-01), pages 3633-3643, XP000973562, ISSN: 0006-4971</text></B562><B562><text>M. SEIFFERT: "Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34+CD38- hematopoietic cells", BLOOD, vol. 97, no. 9, 1 May 2001 (2001-05-01), pages 2741-2749, XP055056672, ISSN: 0006-4971, DOI: 10.1182/blood.V97.9.2741</text></B562><B562><text>W. Y. LEE ET AL: "Novel Structural Determinants on SIRP that Mediate Binding to CD47", THE JOURNAL OF IMMUNOLOGY, vol. 179, no. 11, 19 November 2007 (2007-11-19), pages 7741-7750, XP055497847, ISSN: 0022-1767, DOI: 10.4049/jimmunol.179.11.7741</text></B562><B562><text>X. W. ZHAO ET AL: "CD47-signal regulatory protein-? (SIRP?) interactions form a barrier for antibody-mediated tumor cell destruction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 45, 8 November 2011 (2011-11-08), pages 18342-18347, XP055055636, ISSN: 0027-8424, DOI: 10.1073/pnas.1106550108</text></B562><B562><text>JOANNE E NETTLESHIP ET AL: "Crystal structure of signal regulatory protein gamma (SIRP[gamma]) in complex with an antibody Fab frag", BMC STRUCTURAL BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 13, no. 1, 4 July 2013 (2013-07-04), page 13, XP021156553, ISSN: 1472-6807, DOI: 10.1186/1472-6807-13-13</text></B562><B562><text>SEIFFERT, M. ET AL.: 'Human Signal-Regulatory Protein Is Expressed on Normal, But Not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving Its Counterreceptor CD 47' BLOOD vol. 94, no. 11, 1999, pages 3633 - 3643, XP000973562</text></B562><B562><text>SEIFFERT, M. ET AL.: 'Signal-regulatory protein a (SIRPa) but not SIRPb is involved in T- cell activation, binds to CD 47 with high affinity, and is expressed on immature CD 34+ CD 38- hematopoietic cells' BLOOD vol. 97, no. 9, pages 2741 - 2749, XP055056672</text></B562><B562><text>LEE, W. ET AL.: 'Novel Structural Determinants on SIRPa that Mediate Binding to CD 47' THE JOURNAL OF IMMUNOLOGY vol. 179, 2007, pages 7741 - 7750, XP055497847</text></B562><B562><text>ZHAO, X. ET AL.: 'CD 47-signal regulatory protein-a (SIRPa) interactions form a barrier for antibody-mediated tumor cell destruction' PNAS USA vol. 108, no. 45, 2011, pages 18342 - 18347, XP055055636</text></B562><B562><text>NETTLESHIP, J. ET AL.: 'Crystal structure of signal regulatory protein gamma (SIRPg) in complex with an antibody Fab fragment' BMC STRUCTURAL BIOLOGY vol. 13, 2013, pages 1 - 8, XP021156553</text></B562><B565EP><date>20200327</date></B565EP></B560></B500><B600><B620EP><parent><cdoc><dnum><anum>22179377.1</anum></dnum><date>20220616</date></cdoc></parent></B620EP></B600><B700><B720><B721><snm>PONS, Jaume</snm><adr><str>c/o ALX ONCOLOGY INC.
866 Malcolm Road
Suite 100</str><city>Burlingame, CA 94010</city><ctry>US</ctry></adr></B721><B721><snm>SIM, Bang Janet</snm><adr><str>c/o ALX ONCOLOGY INC.
866 Malcolm Road
Suite 100</str><city>Burlingame, CA 94010</city><ctry>US</ctry></adr></B721><B721><snm>WAN, Hong</snm><adr><str>c/o ALX ONCOLOGY INC.
866 Malcolm Road
Suite 100</str><city>Burlingame, CA 94010</city><ctry>US</ctry></adr></B721><B721><snm>KUO, Tracy Chia-Chien</snm><adr><str>c/o ALX ONCOLOGY INC.
866 Malcolm Road
Suite 100</str><city>Burlingame, CA 94010</city><ctry>US</ctry></adr></B721><B721><snm>KAUDER, Steven Elliot</snm><adr><str>c/o ALX ONCOLOGY INC.
866 Malcolm Road
Suite 100</str><city>Burlingame, CA 94010</city><ctry>US</ctry></adr></B721><B721><snm>HARRIMAN, William Don</snm><adr><str>c/o Crystal Bioscience Inc.
5980 Horton Street
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