(19)

(11)

EP 3 519 827 A1

(12)

(43) Date of publication: 07.08.2019 Bulletin 2019/32 (21) Application number: 17791768.9 (22) Date of filing: 26.09.2017

(51) International Patent Classification (IPC):  G01N 33/574(2006.01) G01N 33/92(2006.01) C07K 16/28(2006.01) (86) International application number: PCT/US2017/053370 (87) International publication number: WO 2018/064013 (05.04.2018 Gazette 2018/14)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 27.09.2016 US 201662400589 P 11.10.2016 US 201662406727 P 03.04.2017 US 201762480994 P 17.05.2017 US 201762507580 P (71) Applicant: Oncologie, Inc. Waltham, MA 02451 (US)

(72) Inventors: TANG, Min Tustin, CA 92780 (US) SHAN, Joseph, S. Tustin, CA 92780 (US) KING, Steven,W. Tustin, CA 92780 (US) CHANG, Connie Tustin, CA 92780 (US) BROWN, Michael, A. Tustin, CA 92780 (US) (74) Representative: Miller, David James et al Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG London SE1 9SG (GB)