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EP 3 525 798 A1

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(43) Date of publication: 21.08.2019 Bulletin 2019/34 (21) Application number: 17861108.3 (22) Date of filing: 12.10.2017

(51) International Patent Classification (IPC):  A61K 31/7105(2006.01) A61K 39/395(2006.01) A61K 48/00(2006.01) A61K 39/00(2006.01) A61K 45/00(2006.01) A61P 7/00(2006.01) (86) International application number: PCT/US2017/056386 (87) International publication number: WO 2018/071701 (19.04.2018 Gazette 2018/16)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 13.10.2016 US 201662407979 P 05.01.2017 US 201715399524 27.03.2017 US 201715470647 30.06.2017 US 201762527926 P (71) Applicants: University Of Leicester Leicester, Leicestershire LE1 7RH (GB) Omeros Corporation Seattle, WA 98119 (US)

(72) Inventors: BRUNSKILL, Nigel, John Mountsorrel LE12 7AF (GB) DEMOPULOS, Gregory, A. Mountsorrel LE12 7AF (US) DUDLER, Tom Mountsorrel LE12 7AF (US) SCHWAEBLE, Hans-Wilhelm Mountsorrel LE12 7AF (GB) (74) Representative: Avidity IP  Broers Building Hauser Forum 21 JJ Thomson Avenue Cambridge CB3 0FA Cambridge CB3 0FA (GB)