(19)
(11) EP 3 542 808 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
20.11.2019 Bulletin 2019/47

(43) Date of publication A2:
25.09.2019 Bulletin 2019/39

(21) Application number: 19150368.9

(22) Date of filing: 11.04.2014
(51) International Patent Classification (IPC): 
A61K 35/76(2015.01)
A61K 38/18(2006.01)
A61K 9/14(2006.01)
A61L 31/14(2006.01)
C12N 11/08(2006.01)
C12N 7/01(2006.01)
 A61K 31/7088(2006.01)
A61K 47/34(2017.01)
A61L 31/08(2006.01)
A61P 17/02(2006.01)
C12N 15/866(2006.01)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 12.04.2013 US 201361811203 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
14783183.8 / 2983682

(71) Applicant: MANGOGEN PHARMA INC.
Laval, QC H7V 5B7 (CA)

(72) Inventors:
  • PRAKASH, Satya
    Brossard, Québec J4Y 3J7 (CA)
  • PAUL, Arghya
    Longueuil, Québec J4K 0B2 (CA)
  • SHUM-TIM, Dominique
    Beaconsfield, Québec H9W 6G5 (CA)

(74) Representative: Barker Brettell LLP 
100 Hagley Road Edgbaston
Birmingham B16 8QQ
Birmingham B16 8QQ (GB)

   


(54) THERAPEUTIC VIRAL MICROPARTICLES FOR PROMOTING STENT BIOFUNCTIONALITY AND WOUND HEALING IN VERTEBRATE INDIVIDUALS


(57) The present invention provides viral microparticles comprising genetically-engineered baculovirus embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally incombination with a medical implant such as vascular stent platforms). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as supports comprising the viral microparticles for the locating the viral microparticles in a wound or in the vicinity of a wound.







Search report





















Search report