(19)

(11)

EP 3 544 519 A1

(12)

(43) Date of publication: 02.10.2019 Bulletin 2019/40 (21) Application number: 16922379.9 (22) Date of filing: 23.11.2016

(51) International Patent Classification (IPC):  A61B 17/00(2006.01) A61B 17/94(2006.01) A61F 2/82(2013.01) A61B 17/02(2006.01) A61F 2/00(2006.01) (86) International application number: PCT/US2016/063495 (87) International publication number: WO 2018/097826 (31.05.2018 Gazette 2018/22)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (71) Applicant: University of Maryland, Baltimore Baltimore, MD 21201 (US)	(72) Inventor: WOLF, Jeffrey S. Owings Mills, Maryland 21117 (US) (74) Representative: Chapman, Paul Gilmour  Marks & Clerk LLP 40 Torphichen Street Edinburgh EH3 8JB Edinburgh EH3 8JB (GB)