(19)
(11) EP 3 552 615 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
02.03.2022 Bulletin 2022/09

(45) Mention of the grant of the patent:
26.01.2022 Bulletin 2022/04

(21) Application number: 19174121.4

(22) Date of filing: 16.07.2015
(51) International Patent Classification (IPC): 
A61K 35/768(2015.01)
A61K 35/765(2015.01)
A61K 47/02(2006.01)
A61K 35/761(2015.01)
A61K 35/766(2015.01)
C07K 16/28(2006.01)
C12N 9/80(2006.01)
C07K 16/18(2006.01)
A61K 9/00(2006.01)
A61K 9/08(2006.01)
A61K 35/763(2015.01)
C07K 14/535(2006.01)
C12N 9/10(2006.01)
A61K 45/06(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 35/765; A61K 35/761; A61K 35/763; A61K 35/766; C07K 2317/76; A61K 47/02; A61K 9/08; A61K 35/768; A61K 9/0019; A61K 2039/505; C07K 14/535; C07K 16/2818; C07K 2317/55; C07K 2317/622; C12N 9/1077; C12N 9/80; C12N 2710/24121; C12N 2710/24132; C12Y 204/02009; C12Y 305/01023; A61P 1/00; A61P 1/16; A61P 11/00; A61P 13/08; A61P 13/12; A61P 35/00

(54)

ONCOLYTIC VIRUS FOR EXPRESSION OF IMMUNE CHECKPOINT MODULATORS

ONKOLYTISCHES VIRUS ZUR EXPRESSION VON IMMUNOLOGISCHEN PRÜFPUNKTMODULATOREN

VIRUS ONCOLYTIQUE POUR L'EXPRESSION DE MODULATEURS DE POINT DE CONTRÔLE IMMUNITAIRE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 16.07.2014 EP 14306153

(43) Date of publication of application:
16.10.2019 Bulletin 2019/42

(62) Application number of the earlier application in accordance with Art. 76 EPC:
15738359.7 / 3169341

(73) Proprietor: TRANSGENE
67400 Illkirch Graffenstaden (FR)

(72) Inventors:
  • SILVESTRE, Nathalie
    67120 ERGERSHEIM (FR)
  • GEIST, Michel
    67170 BRUMATH (FR)
  • RITTNER, Karola
    67100 STRASBOURG (FR)
  • MARCHAND, Jean-Baptiste
    67210 OBERNAI (FR)
  • THIOUDELLET, Christine
    67000 STRASBOURG (FR)

(74) Representative: Regimbeau 
20, rue de Chazelles
75847 Paris Cedex 17
75847 Paris Cedex 17 (FR)


(56) References cited: : 
WO-A1-2009/065546
WO-A1-2019/178101
CN-A- 108 165 536
WO-A1-2014/047350
WO-A1-2020/049001
CN-A- 110 218 707
   
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  • J. D. DIAS ET AL: "Targeted Chemotherapy for Head and Neck Cancer with a Chimeric Oncolytic Adenovirus Coding for Bifunctional Suicide Protein FCU1", CLINICAL CANCER RESEARCH, vol. 16, no. 9, 13 April 2010 (2010-04-13) , pages 2540-2549, XP055214478, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-09-2974
  • T DU ET AL: "Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers", CANCER GENE THERAPY, vol. 21, no. 8, 18 July 2014 (2014-07-18), pages 340-348, XP055214039, ISSN: 0929-1903, DOI: 10.1038/cgt.2014.34
  • CHRISTINE E ENGELAND ET AL: "CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy", MOLECULAR THERAPY, vol. 22, no. 11, 26 August 2014 (2014-08-26), pages 1949-1959, XP055158410, ISSN: 1525-0016, DOI: 10.1038/mt.2014.160
  • MAXINE BAUZON ET AL: "Armed Therapeutic Viruses - A Disruptive Therapy on the Horizon of Cancer Immunotherapy", FRONTIERS IN IMMUNOLOGY, vol. 5, 1 February 2014 (2014-02-01), XP055214432, DOI: 10.3389/fimmu.2014.00074
  • DON B GAMMON ET AL: "Vaccinia Virus-Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis", PL O S PATHOGENS (PRINT), PUBLIC LIBRARY OF SCIENCE, US, vol. 6, no. 7, 8 July 2010 (2010-07-08), pages e1000984-1, XP008150295, ISSN: 1553-7366, DOI: 10.1371/JOURNAL.PPAT.1000984
  • KYLE G. POTTS ET AL: "Oncolytic Viruses in the Treatment of Bladder Cancer", ADVANCES IN UROLOGY, vol. 2012, 1 January 2012 (2012-01-01), pages 1-11, XP055443442, ISSN: 1687-6369, DOI: 10.1155/2012/404581
  • WOO YANGHEE ET AL: "Novel Chimeric Immuno-Oncolytic Virus CF33-hNIS-antiPDL1 for the Treatment of Pancreatic Cancer", JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, COLLEGE, CHICAGO, IL, US, vol. 230, no. 4, 4 February 2020 (2020-02-04), pages 709-717, XP086103159, ISSN: 1072-7515, DOI: 10.1016/J.JAMCOLLSURG.2019.12.027 [retrieved on 2020-02-04]
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).