(19)
(11) EP 3 555 093 A1

(12)

(43) Date of publication:
23.10.2019 Bulletin 2019/43

(21) Application number: 17816799.5

(22) Date of filing: 14.12.2017
(51) International Patent Classification (IPC): 
C07D 471/04(2006.01)
C07D 498/04(2006.01)
A61P 29/00(2006.01)
A61K 31/553(2006.01)
 C07D 487/04(2006.01)
C07D 519/00(2006.01)
A61K 31/55(2006.01)
(86) International application number:
PCT/EP2017/082851
(87) International publication number:
WO 2018/109097 (21.06.2018 Gazette 2018/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD TN

(30) Priority: 16.12.2016 US 201662435567 P

(71) Applicant: F. Hoffmann-La Roche AG
4070 Basel (CH)

(72) Inventors:
  • PATEL, Snahel
    South San Francisco, California 94080 (US)
  • HAMILTON, Gregory
    South San Francisco, California 94080 (US)

(74) Representative: Sauer, Frank 
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel
4070 Basel (CH)

   


(54) INHIBITORS OF RIP1 KINASE AND METHODS OF USE THEREOF