COMPOUND FOR ENHANCING THE COUPLING DEGREE OF COMPLEX TRPV4-KCA2.3 AND ANTI-HYPERTENSION APPLICATIONS THEREOF

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EP 3 556 747 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	18.11.2020 Bulletin 2020/47

(45)	Mention of the grant of the patent:
	26.08.2020 Bulletin 2020/35

(21)	Application number: 17904901.0

(22)	Date of filing: 12.05.2017

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International Patent Classification (IPC):

C07D 239/90^(2006.01)
A61P 9/12^(2006.01)

A61K 31/517^(2006.01)

(86)	International application number:
	PCT/CN2017/084079

(87)	International publication number:
	WO 2018/184274 (11.10.2018 Gazette 2018/41)

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COMPOUND FOR ENHANCING THE COUPLING DEGREE OF COMPLEX TRPV4-KCA2.3 AND ANTI-HYPERTENSION APPLICATIONS THEREOF

VERBINDUNG ZUR VERBESSERUNG DES KOPPLUNGGRADS EINES TRPV4-KCA2.3-KOMPLEXES UND ANTIHYPERTENSIVE ANWENDUNGEN DER VERBINDUNG

COMPOSÉ POUR AMÉLIORER LE DEGRÉ DE COUPLAGE DU COMPLEXE TRPV4-KCA2.3 ET APPLICATIONS ANTI-HYPERTENSIVES DUDIT COMPOSÉ

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

07.04.2017 CN 201710224218

(43)	Date of publication of application:
	23.10.2019 Bulletin 2019/43

(73)	Proprietor: Jiangnan University
	Wuxi, Jiangsu 214122 (CN)

(72)	Inventors:
	MA, Xin Wuxi Jiangsu 214122 (CN) HE, Dongxu Wuxi Jiangsu 214122 (CN) TANG, Chunlei Wuxi Jiangsu 214122 (CN) ZHANG, Peng Wuxi Jiangsu 214122 (CN) CHEN, Zhen Wuxi Jiangsu 214122 (CN) CAI, Yanfei Wuxi Jiangsu 214122 (CN)

(74)	Representative: Hanna Moore + Curley
	Garryard House 25/26 Earlsfort Terrace Dublin 2, D02 PX51 Dublin 2, D02 PX51 (IE)

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References cited: :

WO-A2-2007/056124

CN-A- 101 400 672

SUN ZHONGYA ET AL: "Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 27, no. 9, 9 March 2017 (2017-03-09), pages 2003-2009, XP029968158, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2017.03.012
I. BORZA ET AL.: "Kynuernic acid amides as novel NR2B selective NMDA receptor antagonists", BIOORG. MED. CHEM., vol. 17, 13 October 2006 (2006-10-13), pages 406-409, XP002795101,
Ma Xin: "The Function of TRPV4-SKCa Ion Tunnel Complex in the Arteriole Flow and Blood Pressure Regulation", Journal of Ningxia Medical University, vol. 33, 31 August 2011 (2011-08-31), page 181, XP009515530,
SUN, CHUNYUAN et al.: "High Salt Diet Enhances the Physical Coupling between TRPV4 and cPLA2", Chinese Pharmacological Bulletin, vol. 32, no. 12, 31 December 2016 (2016-12-31), pages 1718-1723, XP009515501, ISSN: 1001-1978

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