(19)

(11)

EP 3 558 223 A1

(12)

(43) Date of publication: 30.10.2019 Bulletin 2019/44 (21) Application number: 17825142.7 (22) Date of filing: 08.12.2017

(51) International Patent Classification (IPC):  A61K 8/26(2006.01) A61K 8/88(2006.01) A61K 8/86(2006.01) A61K 8/28(2006.01) A61K 8/90(2006.01) A61Q 15/00(2006.01) (86) International application number: PCT/EP2017/081981 (87) International publication number: WO 2018/114387 (28.06.2018 Gazette 2018/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD TN (30) Priority: 22.12.2016 GB 201621967 (71) Applicant: Croda International PLC Goole, East Yorkshire DN14 9AA (GB)	(72) Inventors: COULSON, Adeline Mary Doncaster South Yorkshire DN4 7BB (GB) DE SOUZA, Aline Moreira St. Helens, WA10 5PL (GB) (74) Representative: Craven, Ian et al Croda Europe Limited Intellectual Property Department Cowick Hall Snaith Goole Yorkshire DN14 9AA Goole Yorkshire DN14 9AA (GB)